JWH-081 is an
analgesic chemical from the
naphthoylindole family, which acts as a
cannabinoid agonist at both the CB
1 and CB
2 receptors.
With a
Ki of 1.2nM it is fairly selective for the CB
1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB
2(12.4nM).
It was discovered by and named after
John W. Huffman
John William Huffman (1932–2022) was a professor of organic chemistry at Clemson University who first synthesised novel cannabinoids. His research, funded by the National Institute on Drug Abuse, was focused on making a drug to target endocanna ...
.
JWH-081 may be neurotoxic to animals when administered in high doses.
Legal status
In the United States, JWH-081 is a
Schedule I Controlled Substance.
As of October 2015, JWH-081 is a controlled substance in China.
See also
*
JWH-018
*
JWH-098
*
JWH-164
*
JWH-198
JWH-198 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB1 re ...
*
JWH-210
References
Designer drugs
JWH cannabinoids
Naphthoylindoles
Phenol ethers
CB1 receptor agonists
{{cannabinoid-stub