Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat

tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, i ...

. It is a

fixed dose combination A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form. Terms like "combination drug" or "combination drug product" can be common shorthand for a FDC prod ...

isoniazid Isoniazid, also known as isonicotinic acid hydrazide (INH), is an antibiotic used for the treatment of tuberculosis. For active tuberculosis it is often used together with rifampicin, pyrazinamide, and either streptomycin or ethambutol. For la ...

and rifampicin (rifampin). It is used together with other antituberculosis medication. It is taken by mouth. It is on the

World Health Organization's List of Essential Medicines The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...

Adverse effects and safety

Side effects are those of the underlying medications. Common side effects include poor coordination, poor appetite, nausea, numbness, and feeling tired. More severe side effects include

liver problems Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. Signs and symptoms Some of the s ...

. Use is generally not recommended in children. It is unclear if use is safe in pregnancy.

References

{{DEFAULTSORT:Isoniazid Rifampicin Wikipedia medicine articles ready to translate World Health Organization essential medicines