Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually specialize ...

. Along with

Aaron Ciechanover Aaron Ciechanover ( ; he, אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Earl ...

and Avram Hershko, he was awarded the 2004

Nobel Prize in Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

for the discovery of

ubiquitin Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Fo ...

-mediated protein degradation.

Education and early life

Rose was born in

Brooklyn, New York Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York. Kings County is the most populous county in the State of New York, and the second-most densely populated county in the United States, be ...

, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' Rose attended

Washington State University Washington State University (Washington State, WSU, or informally Wazzu) is a public land-grant research university with its flagship, and oldest, campus in Pullman, Washington. Founded in 1890, WSU is also one of the oldest land-grant uni ...

for one year prior to serving in the Navy during World War II. Upon returning from the war he received his

Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...

degree in 1948 and his

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...

in biochemistry in 1952, both from the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

. He did his post-doctoral studies at

NYU New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-Secretary of the Treasury Albert Gallatin. In 1832, the ...

Career and research

Rose served on the faculty of

Yale School of Medicine The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary te ...

's department of biochemistry from 1954 to 1963. He then joined the

Fox Chase Cancer Center Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are loca ...

in 1963 and stayed there until he retired in 1995. He joined

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a Private university, private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest- ...

during the 1970s and served as a Professor of Physical Biochemistry. He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004. Irwin (Ernie) trained several

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

fellows while at the

in Philadelphia. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.

Awards and honors

Rose was awarded the Nobel prize in 2004.

Personal life

Rose was married to Zelda Budenstein and had four children. He died on June 2, 2015 at

Deerfield, Massachusetts Deerfield is a town in Franklin County, Massachusetts, United States. Settled near the Connecticut River in the 17th century during the colonial era, the population was 5,090 as of the 2020 census. Deerfield is part of the Springfield, Massac ...

. His wife died in 2016.

References

External links

* including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' {{DEFAULTSORT:Rose, Irwin 1926 births 2015 deaths American biologists American Nobel laureates Jewish American scientists Members of the United States National Academy of Sciences Nobel laureates in Chemistry People from Spokane, Washington University of California, Irvine faculty University of Chicago alumni United States Navy personnel of World War II Fox Chase Cancer Center people