Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Interactions
ITGB4 has been shown to
interact
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with
Collagen, type XVII, alpha 1,
EIF6
Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functi ...
and
Erbin.
See also
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
*
List of target antigens in pemphigoid
Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
O ...
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia*
ITGB4Info with links in th
Cell Migration Gateway
{{Integrins
Clusters of differentiation
Integrins