Integrin alpha-IIb is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''ITGA2B''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
. ITGA2B, also known as
CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.
In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Interactions
ITGA2B has been shown to
interact
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with
AUP1
Ancient ubiquitous protein 1 is a protein that in humans is encoded by the ''AUP1'' gene.
Function
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be ...
and
CLNS1A
Methylosome subunit pICln is a protein that in humans is encoded by the ''CLNS1A'' gene.
Interactions
CLNS1A has been shown to interact with:
* ITGA2B,
* PRMT5,
* SNRPD1, and
* SNRPD3.
See also
* Chloride channel
Chloride channels are ...
.
See also
*
Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
*
Glycoprotein IIb/IIIa
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. The complex is formed via calcium ...
References
Further reading
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External links
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Clusters of differentiation
Integrins
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