Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
, and the protein resulting from it.
Protein structure
The protein encoded by this gene is a member of the
intercellular adhesion molecule
In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events. ...
(ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.
Protein functions
ICAM-2 molecules regulate
spermatid
The spermatid is the haploid male gametid that results from division of secondary spermatocytes. As a result of meiosis, each spermatid contains only half of the genetic material present in the original primary spermatocyte.
Spermatids are co ...
adhesion on
Sertoli cell
Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis (the production of sperm) as a structural component of the seminiferous tubules. They are activated by follicle-stimu ...
on the apical side of the
blood-testis barrier (towards the
lumen), thus playing a major role in
spermatogenesis.
This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Interactions
ICAM2 has been shown to
interact
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with
EZR.
It has also been shown to bind to P9 (Uniprot
B2UM07, a secreted protein from
Akkermansia muciniphila
''Akkermansia muciniphila'' is a human intestinal symbiont, isolated from human feces. It is a mucin-degrading bacterium belonging to the genus, ''Akkermansia'', discovered in 2004 by Muriel Derrien and Willem de Vos at Wageningen University of ...
.
See also
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophen ...
References
Further reading
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External links
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PDBe-KBprovides an overview of all the structure information available in the PDB for Human Intercellular adhesion molecule 2 (ICAM2)
Clusters of differentiation
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