Hopantenic acid (homopantothenic acid), also known as N-pantoyl-GABA, is a
central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...
depressant
A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain. Depressants are also colloquially referred to as downers as they lower the ...
. Formulated as the
calcium
Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar t ...
salt
Salt is a mineral composed primarily of sodium chloride (NaCl), a chemical compound belonging to the larger class of salts; salt in the form of a natural crystalline mineral is known as rock salt or halite. Salt is present in vast quant ...
, it is used as a pharmaceutical drug in the
Russian Federation
Russia (, , ), or the Russian Federation, is a transcontinental country spanning Eastern Europe and Northern Asia. It is the largest country in the world, with its internationally recognised territory covering , and encompassing one-eig ...
for a variety of neurological, psychological and psychiatric conditions and sold as Pantogam (russian: Пантогам). It is not approved for use in Europe or the United States.
Chemistry
Hopantenic acid is a
homologue of
pantothenic acid
Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, ...
. While pantothenic acid is the
amide
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it i ...
of
D-pantoate and
β-alanine, hopantenic acid is the amide of
D-pantoate and
γ-aminobutyric acid (GABA). This change leads to an additional CH
2 in the molecule.
See also
*
Methyl pentanoate
*
Menthyl isovalerate
References
External links
pantogab (hopantenic acid)- Curehunter.com
{{GABAergics
Drugs acting on the nervous system
GABA analogues