Hispidulin is a naturally occurring
flavone with potential
antiepileptic
Anticonvulsants (also known as antiepileptic drugs or recently as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of b ...
activity in rats and gerbils.
[The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects, Dominique Kavvadias et al, British Journal of Pharmacology (2004) 142, 811–820] It is found in plants including ''
Grindelia argentina'', ''
Arrabidaea chica'', ''
Saussurea involucrate'', ''
Crossostephium chinense'', ''
Artemisia'', and ''
Salvia
''Salvia'' () is the largest genus of plants in the sage family Lamiaceae, with nearly 1000 species of shrubs, herbaceous perennials, and annuals. Within the Lamiaceae, ''Salvia'' is part of the tribe Mentheae within the subfamily Nepetoi ...
''.
[
]
Complementary medicine
In traditional and complementary medicine it is claimed to have "antioxidant, antifungal, anti-inflammatory, antimutagenic, and antineoplastic properties".[Kanika Patel, Dinesh Kumar Patel, Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report, Journal of Traditional and Complementary Medicine, 2016, ISSN 2225-4110, https://dx.doi.org/10.1016/j.jtcme.2016.11.003.]
Notes
Anticonvulsants
O-methylated flavones
Flavones
GABAA receptor positive allosteric modulators
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