Heinz Lehmann
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Heinz Edgar Lehmann (July 17, 1911 – April 7, 1999) was a German-born
Canadian Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of ...
psychiatrist best known for his use of
chlorpromazine Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar di ...
for the treatment of
schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wit ...
in 1950s and "truly the father of modern
psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on mo ...
."


Early life

Born in
Berlin Berlin ( , ) is the capital and List of cities in Germany by population, largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's List of cities in the European Union by population within ci ...
,
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
, he was educated at the
University of Freiburg The University of Freiburg (colloquially german: Uni Freiburg), officially the Albert Ludwig University of Freiburg (german: Albert-Ludwigs-Universität Freiburg), is a public research university located in Freiburg im Breisgau, Baden-Württemb ...
, the
University of Marburg The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the wor ...
, the
University of Vienna The University of Vienna (german: Universität Wien) is a public research university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world. With its long and rich hist ...
, and the
University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative ...
. He emigrated to Canada in 1937. Beginning his new life working at the
Montreal Children's Hospital Montreal Children's Hospital (french: Hôpital de Montréal pour enfants) is a children's hospital in Montreal, Quebec, Canada. Founded in 1904, it is affiliated with the McGill University Health Centre (MUHC) and McGill University, Faculty of M ...
in Montreal where he improved his English until he was appointed junior psychiatrist at then Verdun Protestant Hospital, now called
Douglas Mental Health University Institute The Douglas Mental Health University Institute (french: Institut universitaire en santé mentale Douglas; formerly the Douglas Hospital and originally the Protestant Hospital for the Insane) is a Canadian psychiatric hospital located in the borou ...
, on the eve of the Second World War. He lived on the grounds of this hospital where he met his future wife Annette, a nurse, and their son François was born in 1944.


Hospital work in Canada

In 1947, he was appointed the clinical director of Montreal's Douglas Hospital. From 1971 to 1975, he was the chair of the
McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec Montreal ( ; officially Montréal, ) is the second-most populous city in Canada and most populous ...
Department of Psychiatry. He was also a humane lecturer in psychiatry in 1952, and was able to give empathetic lectures on the plight of people suffering from anxiety, depression obsessions, paranoia etc. No one at that time had been able to understand or help psychotic and depressed patients, who filled mental hospitals around the world, so when the first big breakthrough chlorpromazine(Largactil) arrived from France in 1953 and then imipramine (Tofranil), which came from German-speaking Switzerland in 1958, they both showed promise. He helped to promote them in North America which ignited the drug revolution. He was ahead of his time in that he supported research in the use of the active ingredient
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
to alleviate anxiety.


Early Clinical Drug Evaluation Unit (ECDEU)

In 1961 Dr. Lehmann became involved in a new
US Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services concerned with public health, containing nine out of the department's twelve operating divisions. The Assistant S ...
Program initiative which met to exchange observations and findings on new psychotropics. Although based in Montreal, Canada, it became one of the first units in this network. He invited Thomas A. Ban, his senior psychiatrist and chief of the clinical research service at the hospital, to become his co-principal investigator. This began a close collaboration over an 18-year period that researched most of the psychotropic drugs marketed in North America during the 1960s and 70s. Their findings and observations were shared internationally in articles and at conferences and had a profound impact on the evolution of psychopharmacology as a discipline.


Le Dain Commission

From 1969 to 1972, he was one of the five members of the Le Dain Commission, a royal commission appointed in Canada to study the non-medical use of drugs. He was an advocate for decriminalization of marijuana.


DSM work

In 1973, he was a member of the Nomenclature Committee of the
American Psychiatric Association The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world. It has more than 37,000 members are involv ...
that decided to drop
homosexuality Homosexuality is romantic attraction, sexual attraction, or sexual behavior between members of the same sex or gender. As a sexual orientation, homosexuality is "an enduring pattern of emotional, romantic, and/or sexual attractions" to pe ...
from the Diagnostic and Statistical Manual of Mental Disorders, i.e. to depathologize it.


Honors and awards

In acknowledgment of his important contributions, he received the
Lasker Award The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was ...
in 1957 and the Stratton Award of the American Psychopathological Association in 1962. In 1970 he was made a Fellow of the Royal Society of Canada and, in 1976, he was made an Officer of the
Order of Canada The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the cen ...
. He was inducted into the Canadian Medical Hall of Fame in 1998.


Heinz Lehmann Award

In 1999, the Canadian College of Neuropsychopharmacology established the Heinz Lehmann Award in his honor, given in recognition of outstanding contributions to research in
neuropsychopharmacology Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (study of effects of drugs on the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails ...
in Canada. There are also several other awards including the Heinz Lehmann Award of Excellence of the Quebec Psychiatric Association; and the Heinz E. Lehmann Research Award, which was established by the New York State Office of Mental Health.


References

* * 1911 births 1999 deaths Canadian psychiatrists Fellows of the Royal Society of Canada German emigrants to Canada Officers of the Order of Canada McGill University faculty Physicians from Berlin 20th-century Canadian physicians Recipients of the Lasker-DeBakey Clinical Medical Research Award {{psychiatrist-stub