Gossypetin, also known as 3,5,7,8,3',4'-hexahydroxyflavone, is a

flavonol Flavonols are a class of flavonoids that have the 3-hydroxyflavone backbone (IUPAC name : 3-hydroxy-2-phenylchromen-4-one). Their diversity stems from the different positions of the phenolic -OH groups. They are distinct from flavanols (with " ...

, a type of flavonoid. It has been isolated from the flowers and the calyx of ''

Hibiscus sabdariffa Roselle (''Hibiscus sabdariffa'') is a species of flowering plant in the genus ''Hibiscus'' that is native to Africa, most likely West Africa and also found in India especially Maharashtra with local name ambali. In the 16th and early 17th cent ...

'' (roselle) and exhibits a strong

antibacterial An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention ...

activity. The compound has also been found to act as an antagonist of

TrkB Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the ''NTRK2'' gene. TrkB is a recepto ...

. Recently it was shown that gossypetin has

radioprotective Nuclear safety is defined by the International Atomic Energy Agency (IAEA) as "The achievement of proper operating conditions, prevention of accidents or mitigation of accident consequences, resulting in protection of workers, the public and the ...

activity. The enzyme 8-hydroxyquercetin 8-''O''-methyltransferase uses ''S''-adenosyl methionine and gossypetin to produce ''S''-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone. In 2022, a study in an animal model using intragastric administration suggested that the flavonoid gossypetin facilitated the clearance of beta-amyloid in the brain and is a promising target for the study of treatments for Alzheimer's Disease by enhancing microglial phagocytic activity against Aβ.Jo, K.W., Lee, D., Cha, D.G. et al.,
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
', Alzheimer's Research & Therapy, October 21, 2022 - Alz Res Therapy 14, 158 (2022)

References

Aromatase inhibitors Catechols Flavonols Hydroxyquinols TrkB antagonists {{Aromatic-stub

See also

References