Glemanserin (

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) (developmental code name MDL-11,939) is a drug which acts as a potent and selective 5-HT_2A receptor antagonist. The first truly selective 5-HT_2A ligand to be discovered, glemanserin resulted in the development of the widely used and even more potent and selective 5-HT_2A receptor antagonist volinanserin (MDL-100,907), which is a fluorinated analogue. Though it was largely superseded in

scientific research The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific m ...

by volinanserin, glemanserin was investigated clinically for the treatment of

generalized anxiety disorder Generalized anxiety disorder (GAD) is a mental and behavioral disorder, specifically an anxiety disorder characterized by excessive, uncontrollable and often irrational worry about events or activities. Worry often interferes with daily function ...

. However, it was ultimately found to be ineffective and was not marketed.

References

5-HT2A antagonists Secondary alcohols Phenol ethers Piperidines {{nervous-system-drug-stub

See also

References