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George Wells Beadle (October 22, 1903 – June 9, 1989) was an American scientist in the field of genetics, and Nobel Prize in Physiology or Medicine Nobel laureate
Nobel laureate
who with Edward Tatum
Edward Tatum
discovered the role of genes in regulating biochemical events within cells in 1958.[2][3] Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa
Neurospora crassa
to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments led them to propose a direct link between genes and enzymatic reactions, known as the One gene-one enzyme hypothesis.[4]

Contents

1 Education and early life 2 Career 3 Awards and honors 4 Personal life 5 Notes and references 6 Further reading

Education and early life[edit] George Wells Beadle was born in Wahoo, Nebraska. He was the son of Chauncey Elmer Beadle and Hattie Albro, who owned and operated a 40-acre (160,000 m2) farm nearby.[5] George was educated at the Wahoo High School and might himself have become a farmer if one of his teachers at school had not directed his mind towards science and persuaded him to go to the College of Agriculture in Lincoln, Nebraska. In 1926 he took his Bachelor of Science
Bachelor of Science
degree at the University of Nebraska
Nebraska
and subsequently worked for a year with Professor F.D. Keim, who was studying hybrid wheat. In 1927 he took his Master of Science
Master of Science
degree, and Professor Keim secured for him a post as Teaching Assistant at Cornell University, where he worked, until 1931, with Professors R.A. Emerson and L.W. Sharp on Mendelian asynapsis in Zea mays.[6] For this work he obtained, in 1931, his Doctor of Philosophy
Doctor of Philosophy
degree.[6] Career[edit] In 1931 Beadle was awarded a National Research Council Fellowship at the California Institute of Technology
California Institute of Technology
at Pasadena, where he remained from 1931 until 1936. During this period he continued his work on Indian corn and began, in collaboration with Professors Theodosius Dobzhansky, S. Emerson, and Alfred Sturtevant, work on crossing-over in the fruit fly, Drosophila melanogaster.[citation needed] In 1935 Beadle visited Paris
Paris
for six months to work with Professor Boris Ephrussi at the Institut de Biologie physico-chimique. Together they began the study of the development of eye pigment in Drosophila which later led to the work on the biochemistry of the genetics of the fungus Neurospora for which Beadle and Edward Lawrie Tatum were together awarded the 1958 Nobel Prize for Physiology or Medicine. In 1936 Beadle left the California Institute of Technology
California Institute of Technology
to become Assistant Professor of Genetics
Genetics
at Harvard University. A year later he was appointed Professor of Biology (Genetics) at Stanford University and there he remained for nine years, working for most of this period in collaboration with Tatum. In 1946 he returned to the California Institute of Technology as Professor of Biology and Chairman of the Division of Biology. Here he remained until January 1961 when he was elected Chancellor of the University of Chicago
Chicago
and, in the autumn of the same year, President of this University. After retiring, Beadle undertook a remarkable experiment in maize genetics. In several laboratories he grew a series of Teosinte/Maize crosses. Then he crossed these progeny with each other. He looked for the rate of appearance of parent phenotypes among this second generation. The vast majority of these plants were intermediate between maize and Teosinte
Teosinte
in their features, but about 1 in 500 of the plants were identical to either the parent maize or the parent teosinte. Using the mathematics of Mendelian genetics, he calculated that this showed a difference between maize and teosinte of about 5 or 6 genetic loci. This demonstration was so compelling that most scientists now agree that Teosinte
Teosinte
is the wild progenitor of maize.[7][8] During his career, Beadle has received many honors. These include the Honorary Doctor of Science of the following Universities: Yale (1947), Nebraska
Nebraska
(1949), Northwestern University (1952), Rutgers University (1954), Kenyon College (1955), Wesleyan University (1956), the University of Birmingham
University of Birmingham
and the University of Oxford, England (1959), Pomona College (1961), and Lake Forest College (1962). In 1962 he was also given the honorary degree of LL.D. by the University of California, Los Angeles. He was elected a Fellow of the American Academy of Arts and Sciences in 1946.[9] He also received the Lasker Award of the American Public Health Association (1950), the Dyer Award (1951), the Emil Christian Hansen Prize of Denmark (1953), the Albert Einstein Commemorative Award in Science (1958), the Nobel Prize in Physiology or Medicine 1958 with Edward Tatum
Edward Tatum
and Joshua Lederberg, the National Award of the American Cancer Society (1959), and the Kimber Genetics
Genetics
Award of the National Academy of Sciences
National Academy of Sciences
(1960). Awards and honors[edit] In addition to the Nobel Prize, Beadle received numerous other awards. Beadle was a member of several learned societies, among which the National Academy of Sciences
National Academy of Sciences
(Chairman of Committee on Genetic Effects of Atomic Radiation), the Genetics
Genetics
Society of America (President in 1946), the American Association for the Advancement of Science (President in 1955), the American Cancer Society (Chairman of Scientific Advisory Council), the Royal Society
Royal Society
of London,[1] and the Danish Royal Academy of Science. The George W. Beadle Award of the Genetics
Genetics
Society of America is named in his honor. George Beadle Middle School in Millard, Nebraska
Nebraska
(Part of the Millard Public Schools district) was named after him. It opened in 2001. The Beadle Center, which houses the Department of Biochemistry at the University of Nebraska-Lincoln, is also named after George Beadle. Personal life[edit] Beadle was married twice. By his first wife he had a son, David, who now lives at The Hague, the Netherlands. His second wife, Muriel McClure (1915-1994), a well-known writer, was born in California. Beadle's chief hobbies were rockclimbing, skiing, and gardening. He was a member of FarmHouse Fraternity while at the University of Nebraska. George Beadle died on June 9, 1989. He was an atheist.[10] Notes and references[edit]

^ a b Horowitz, N. H. (1995). "George Wells Beadle. 23 October 1903-9 June 1989". Biographical Memoirs of Fellows of the Royal Society. 41: 44–54. doi:10.1098/rsbm.1995.0003.  ^ George W. Beadle — Biographical Memoirs of the National Academy of Sciences ^ Stern, C. (1954). "George W. Beadle". Science. 119 (3086): 229–230. Bibcode:1954Sci...119..229S. doi:10.1126/science.119.3086.229. PMID 13135519.  ^ Beadle, G. W.; Tatum, E. L. (1941). "Genetic Control of Biochemical Reactions in Neurospora". Proceedings of the National Academy of Sciences. 27 (11): 499–506. Bibcode:1941PNAS...27..499B. doi:10.1073/pnas.27.11.499. PMC 1078370 . PMID 16588492.  ^ Beadle, G. W. (1974). "Recollections". Annual Review of Biochemistry. 43 (0): 1–13. doi:10.1146/annurev.bi.43.070174.000245. PMID 4605017.  ^ a b Beadle, George Wells (1930). Genetical and Cytological Studies of Mendelian Asynapsis in Zea mays
Zea mays
(PhD thesis). Cornell University.  ^ Beadle, G. W. (1980). "The ancestry of corn". Scientific American. 242 (1): 112–119. Bibcode:1980SciAm.242a.112B. doi:10.1038/scientificamerican0180-112.  ^ Beadle, George. "The Ancestry of Corn" (PDF). Retrieved 2 July 2014.  ^ " Book
Book
of Members, 1780-2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 28, 2011.  ^ George Beadle, An Uncommon Farmer: The Emergence of Genetics
Genetics
in the 20th Century. CSHL Press. 2003. p. 273. ISBN 9780879696887. Beadle's views on this occasion were somewhat more tempered than David's characterization of him as a "vehement atheist," and from his earliest days "intolerant of religion and other forms of superstition.

Further reading[edit]

Paul Berg and Maxine Singer. George Beadle: An Uncommon Farmer. The Emergence of Genetics
Genetics
in the 20th Century. Cold Springs Harbor Laboratory Press, 2003. ISBN 0-87969-688-5 Key Participants: George Beadle - It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin, and Sickle Cell Anemia

Academic offices

Preceded by Lawrence A. Kimpton President of the University of Chicago 1961–1968 Succeeded by Edward H. Levi

v t e

Laureates of the Nobel Prize in Physiology or Medicine

1901–1925

1901 Emil Behring 1902 Ronald Ross 1903 Niels Finsen 1904 Ivan Pavlov 1905 Robert Koch 1906 Camillo Golgi
Camillo Golgi
/ Santiago Ramón y Cajal 1907 Alphonse Laveran 1908 Élie Metchnikoff
Élie Metchnikoff
/ Paul Ehrlich 1909 Emil Kocher 1910 Albrecht Kossel 1911 Allvar Gullstrand 1912 Alexis Carrel 1913 Charles Richet 1914 Róbert Bárány 1915 1916 1917 1918 1919 Jules Bordet 1920 August Krogh 1921 1922 Archibald Hill
Archibald Hill
/ Otto Meyerhof 1923 Frederick Banting
Frederick Banting
/ John Macleod 1924 Willem Einthoven 1925

1926–1950

1926 Johannes Fibiger 1927 Julius Wagner-Jauregg 1928 Charles Nicolle 1929 Christiaan Eijkman
Christiaan Eijkman
/ Frederick Gowland Hopkins 1930 Karl Landsteiner 1931 Otto Warburg 1932 Charles Scott Sherrington
Charles Scott Sherrington
/ Edgar Adrian 1933 Thomas Morgan 1934 George Whipple
George Whipple
/ George Minot
George Minot
/ William Murphy 1935 Hans Spemann 1936 Henry Dale / Otto Loewi 1937 Albert Szent-Györgyi 1938 Corneille Heymans 1939 Gerhard Domagk 1940 1941 1942 1943 Henrik Dam
Henrik Dam
/ Edward Doisy 1944 Joseph Erlanger
Joseph Erlanger
/ Herbert Gasser 1945 Alexander Fleming
Alexander Fleming
/ Ernst Chain
Ernst Chain
/ Howard Florey 1946 Hermann Muller 1947 Carl Cori / Gerty Cori
Gerty Cori
/ Bernardo Houssay 1948 Paul Müller 1949 Walter Hess / António Egas Moniz 1950 Edward Kendall / Tadeusz Reichstein
Tadeusz Reichstein
/ Philip Hench

1951–1975

1951 Max Theiler 1952 Selman Waksman 1953 Hans Krebs / Fritz Lipmann 1954 John Enders / Thomas Weller / Frederick Robbins 1955 Hugo Theorell 1956 André Cournand / Werner Forssmann
Werner Forssmann
/ Dickinson W. Richards 1957 Daniel Bovet 1958 George Beadle / Edward Tatum
Edward Tatum
/ Joshua Lederberg 1959 Severo Ochoa
Severo Ochoa
/ Arthur Kornberg 1960 Frank Burnet / Peter Medawar 1961 Georg von Békésy 1962 Francis Crick
Francis Crick
/ James Watson
James Watson
/ Maurice Wilkins 1963 John Eccles / Alan Hodgkin / Andrew Huxley 1964 Konrad Bloch / Feodor Lynen 1965 François Jacob
François Jacob
/ André Lwoff / Jacques Monod 1966 Francis Rous / Charles B. Huggins 1967 Ragnar Granit
Ragnar Granit
/ Haldan Hartline / George Wald 1968 Robert W. Holley
Robert W. Holley
/ Har Khorana / Marshall Nirenberg 1969 Max Delbrück
Max Delbrück
/ Alfred Hershey
Alfred Hershey
/ Salvador Luria 1970 Bernard Katz / Ulf von Euler
Ulf von Euler
/ Julius Axelrod 1971 Earl Sutherland Jr. 1972 Gerald Edelman
Gerald Edelman
/ Rodney Porter 1973 Karl von Frisch
Karl von Frisch
/ Konrad Lorenz
Konrad Lorenz
/ Nikolaas Tinbergen 1974 Albert Claude
Albert Claude
/ Christian de Duve
Christian de Duve
/ George Palade 1975 David Baltimore
David Baltimore
/ Renato Dulbecco
Renato Dulbecco
/ Howard Temin

1976–2000

1976 Baruch Blumberg / Daniel Gajdusek 1977 Roger Guillemin / Andrew Schally
Andrew Schally
/ Rosalyn Yalow 1978 Werner Arber
Werner Arber
/ Daniel Nathans
Daniel Nathans
/ Hamilton O. Smith 1979 Allan Cormack / Godfrey Hounsfield 1980 Baruj Benacerraf / Jean Dausset
Jean Dausset
/ George Snell 1981 Roger Sperry / David H. Hubel
David H. Hubel
/ Torsten Wiesel 1982 Sune Bergström
Sune Bergström
/ Bengt I. Samuelsson / John Vane 1983 Barbara McClintock 1984 Niels Jerne / Georges Köhler / César Milstein 1985 Michael Brown / Joseph L. Goldstein 1986 Stanley Cohen / Rita Levi-Montalcini 1987 Susumu Tonegawa 1988 James W. Black / Gertrude B. Elion
Gertrude B. Elion
/ George H. Hitchings 1989 J. Michael Bishop
J. Michael Bishop
/ Harold E. Varmus 1990 Joseph Murray
Joseph Murray
/ E. Donnall Thomas 1991 Erwin Neher
Erwin Neher
/ Bert Sakmann 1992 Edmond Fischer / Edwin G. Krebs 1993 Richard J. Roberts
Richard J. Roberts
/ Phillip Sharp 1994 Alfred G. Gilman
Alfred G. Gilman
/ Martin Rodbell 1995 Edward B. Lewis
Edward B. Lewis
/ Christiane Nüsslein-Volhard
Christiane Nüsslein-Volhard
/ Eric F. Wieschaus 1996 Peter C. Doherty
Peter C. Doherty
/ Rolf M. Zinkernagel 1997 Stanley B. Prusiner 1998 Robert F. Furchgott
Robert F. Furchgott
/ Louis Ignarro
Louis Ignarro
/ Ferid Murad 1999 Günter Blobel 2000 Arvid Carlsson
Arvid Carlsson
/ Paul Greengard
Paul Greengard
/ Eric Kandel

2001–present

2001 Leland H. Hartwell / Tim Hunt
Tim Hunt
/ Paul Nurse 2002 Sydney Brenner
Sydney Brenner
/ H. Robert Horvitz / John E. Sulston 2003 Paul Lauterbur
Paul Lauterbur
/ Peter Mansfield 2004 Richard Axel
Richard Axel
/ Linda B. Buck 2005 Barry Marshall
Barry Marshall
/ Robin Warren 2006 Andrew Fire / Craig Mello 2007 Mario Capecchi
Mario Capecchi
/ Martin Evans
Martin Evans
/ Oliver Smithies 2008 Harald zur Hausen
Harald zur Hausen
/ Luc Montagnier
Luc Montagnier
/ Françoise Barré-Sinoussi 2009 Elizabeth Blackburn
Elizabeth Blackburn
/ Carol W. Greider
Carol W. Greider
/ Jack W. Szostak 2010 Robert G. Edwards 2011 Bruce Beutler
Bruce Beutler
/ Jules A. Hoffmann / Ralph M. Steinman (posthumously) 2012 John B. Gurdon
John B. Gurdon
/ Shinya Yamanaka 2013 James Rothman
James Rothman
/ Randy Schekman
Randy Schekman
/ Thomas C. Südhof 2014 John O'Keefe / May-Britt Moser
May-Britt Moser
/ Edvard Moser 2015 William C. Campbell / Satoshi Ōmura
Satoshi Ōmura
/ Tu Youyou 2016 Yoshinori Ohsumi 2017 Jeffrey C. Hall, Michael Rosbash, Michael W. Young

v t e

Presidents of the University of Chicago

Harper Judson Burton Mason Hutchins Kimpton Beadle Levi Wilson Gray Sonnenschein Randel Zimmer

v t e

Time Persons of the Year

1927–1950

Charles Lindbergh
Charles Lindbergh
(1927) Walter Chrysler
Walter Chrysler
(1928) Owen D. Young
Owen D. Young
(1929) Mohandas Gandhi (1930) Pierre Laval
Pierre Laval
(1931) Franklin D. Roosevelt
Franklin D. Roosevelt
(1932) Hugh S. Johnson
Hugh S. Johnson
(1933) Franklin D. Roosevelt
Franklin D. Roosevelt
(1934) Haile Selassie
Haile Selassie
(1935) Wallis Simpson
Wallis Simpson
(1936) Chiang Kai-shek
Chiang Kai-shek
/ Soong Mei-ling
Soong Mei-ling
(1937) Adolf Hitler
Adolf Hitler
(1938) Joseph Stalin
Joseph Stalin
(1939) Winston Churchill
Winston Churchill
(1940) Franklin D. Roosevelt
Franklin D. Roosevelt
(1941) Joseph Stalin
Joseph Stalin
(1942) George Marshall
George Marshall
(1943) Dwight D. Eisenhower
Dwight D. Eisenhower
(1944) Harry S. Truman
Harry S. Truman
(1945) James F. Byrnes
James F. Byrnes
(1946) George Marshall
George Marshall
(1947) Harry S. Truman
Harry S. Truman
(1948) Winston Churchill
Winston Churchill
(1949) The American Fighting-Man (1950)

1951–1975

Mohammed Mosaddeq (1951) Elizabeth II
Elizabeth II
(1952) Konrad Adenauer
Konrad Adenauer
(1953) John Foster Dulles
John Foster Dulles
(1954) Harlow Curtice
Harlow Curtice
(1955) Hungarian Freedom Fighters (1956) Nikita Khrushchev
Nikita Khrushchev
(1957) Charles de Gaulle
Charles de Gaulle
(1958) Dwight D. Eisenhower
Dwight D. Eisenhower
(1959) U.S. Scientists: George Beadle / Charles Draper / John Enders / Donald A. Glaser / Joshua Lederberg
Joshua Lederberg
/ Willard Libby
Willard Libby
/ Linus Pauling
Linus Pauling
/ Edward Purcell / Isidor Rabi / Emilio Segrè
Emilio Segrè
/ William Shockley
William Shockley
/ Edward Teller / Charles Townes / James Van Allen
James Van Allen
/ Robert Woodward (1960) John F. Kennedy
John F. Kennedy
(1961) Pope John XXIII
Pope John XXIII
(1962) Martin Luther King Jr.
Martin Luther King Jr.
(1963) Lyndon B. Johnson
Lyndon B. Johnson
(1964) William Westmoreland
William Westmoreland
(1965) The Generation Twenty-Five and Under (1966) Lyndon B. Johnson
Lyndon B. Johnson
(1967) The Apollo 8
Apollo 8
Astronauts: William Anders
William Anders
/ Frank Borman
Frank Borman
/ Jim Lovell (1968) The Middle Americans (1969) Willy Brandt
Willy Brandt
(1970) Richard Nixon
Richard Nixon
(1971) Henry Kissinger
Henry Kissinger
/ Richard Nixon
Richard Nixon
(1972) John Sirica
John Sirica
(1973) King Faisal (1974) American Women: Susan Brownmiller / Kathleen Byerly
Kathleen Byerly
/ Alison Cheek / Jill Conway / Betty Ford
Betty Ford
/ Ella Grasso / Carla Hills / Barbara Jordan / Billie Jean King
Billie Jean King
/ Susie Sharp / Carol Sutton / Addie Wyatt (1975)

1976–2000

Jimmy Carter
Jimmy Carter
(1976) Anwar Sadat
Anwar Sadat
(1977) Deng Xiaoping
Deng Xiaoping
(1978) Ayatollah Khomeini (1979) Ronald Reagan
Ronald Reagan
(1980) Lech Wałęsa
Lech Wałęsa
(1981) The Computer (1982) Ronald Reagan
Ronald Reagan
/ Yuri Andropov
Yuri Andropov
(1983) Peter Ueberroth
Peter Ueberroth
(1984) Deng Xiaoping
Deng Xiaoping
(1985) Corazon Aquino
Corazon Aquino
(1986) Mikhail Gorbachev
Mikhail Gorbachev
(1987) The Endangered Earth (1988) Mikhail Gorbachev
Mikhail Gorbachev
(1989) George H. W. Bush
George H. W. Bush
(1990) Ted Turner
Ted Turner
(1991) Bill Clinton
Bill Clinton
(1992) The Peacemakers: Yasser Arafat
Yasser Arafat
/ F. W. de Klerk
F. W. de Klerk
/ Nelson Mandela
Nelson Mandela
/ Yitzhak Rabin
Yitzhak Rabin
(1993) Pope John Paul II
Pope John Paul II
(1994) Newt Gingrich
Newt Gingrich
(1995) David Ho
David Ho
(1996) Andrew Grove
Andrew Grove
(1997) Bill Clinton
Bill Clinton
/ Ken Starr
Ken Starr
(1998) Jeffrey P. Bezos (1999) George W. Bush
George W. Bush
(2000)

2001–present

Rudolph Giuliani (2001) The Whistleblowers: Cynthia Cooper / Coleen Rowley
Coleen Rowley
/ Sherron Watkins (2002) The American Soldier (2003) George W. Bush
George W. Bush
(2004) The Good Samaritans: Bono
Bono
/ Bill Gates
Bill Gates
/ Melinda Gates
Melinda Gates
(2005) You (2006) Vladimir Putin
Vladimir Putin
(2007) Barack Obama
Barack Obama
(2008) Ben Bernanke
Ben Bernanke
(2009) Mark Zuckerberg
Mark Zuckerberg
(2010) The Protester (2011) Barack Obama
Barack Obama
(2012) Pope Francis
Pope Francis
(2013) Ebola Fighters: Dr. Jerry Brown / Dr. Kent Brantly
Kent Brantly
/ Ella Watson-Stryker / Foday Gollah / Salome Karwah
Salome Karwah
(2014) Angela Merkel
Angela Merkel
(2015) Donald Trump
Donald Trump
(2016) The Silence Breakers (2017)

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WorldCat Identities VIAF: 97657524 LCCN: n50005708 ISNI: 0000 0001 1495 8322 GND: 128581301 SUDOC: 032893906 BNF: cb12383464p (data) BIBSYS: 3116790 NDL: 00432614 SN

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