GYKI 52466 is a 2,3- benzodiazepine that acts as an ionotropic glutamate

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

antagonist, which is a non-competitive AMPA receptor antagonist (IC₅₀ values are 10-20, ~ 450 and >> 50 μM for AMPA-, kainate- and NMDA-induced responses respectively), orally-active anticonvulsant, and skeletal muscle relaxant. Unlike conventional 1,4-benzodiazepines, GYKI 52466 and related 2,3-benzodiazepines do not act on GABA_A receptors. Like other AMPA receptor antagonists, GYKI 52466 has anticonvulsant and

neuroprotective Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...

properties.

References

{{Benzodiazepines AMPA receptor antagonists Anticonvulsants Muscle relaxants

See also

References