The
GPCR
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
superfamily is the largest gene family in the human genome containing approximately 800 genes. As the vertebrate superfamily can be phylogenetically grouped into five main families the GRAFS classification system has been proposed.
GRAFS stands for
Glutamate,
Rhodopsin,
Adhesion
Adhesion is the tendency of dissimilar particles or surfaces to cling to one another ( cohesion refers to the tendency of similar or identical particles/surfaces to cling to one another).
The forces that cause adhesion and cohesion can b ...
,
Frizzled
Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.
Species distribution
Fr ...
/
Taste2,
Secretin. They correspond to classical classes C (
class C, glutamate), A (
rhodopsin-like), B2 (
Secretin receptor family, long N-terminal), F (
Frizzled
Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.
Species distribution
Fr ...
/
Smoothened
Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled receptor that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the molecula ...
), and B1+3 (other secretin).
''Taste2'' has more recently considered to be closer to ''Rhodopsin-like'' receptors.
See also
*
G protein-coupled receptor#Classification
References
Human genetics
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