G protein-coupled receptor 128 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
encoded by the ''ADGRG7''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
GPR128 is a member of the
adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing
(GAIN) domain.
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.
Function
Ni et al. showed that ''Gpr128'' deletion in mice causes reduced body weight and induced intestinal contraction frequency.
Clinical significance
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.
Notably, the fused gene was also detected in few healthy individuals.
References
External links
Adhesion GPCR consortium
{{Use dmy dates, date=April 2017
G protein-coupled receptors