G protein-coupled receptor 112 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
encoded by the ''ADGRG4''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
GPR112 is a member of the
adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing
(GAIN) domain.
GPR112 is expressed in human enterochromaffin cells
and in the mouse intestine.
The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.
GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.
References
External links
Adhesion GPCR consortium
{{G protein-coupled receptors
G protein-coupled receptors