Günter Blobel (; May 21, 1936 – February 18, 2018) was a

Silesia Silesia (, also , ) is a historical region of Central Europe that lies mostly within Poland, with small parts in the Czech Republic and Germany. Its area is approximately , and the population is estimated at around 8,000,000. Silesia is split ...

German German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Ger ...

and American

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter ...

and 1999

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell.

Biography

Günter Blobel was born in Waltersdorf in the

Prussia Prussia, , Old Prussian: ''Prūsa'' or ''Prūsija'' was a German state on the southeast coast of the Baltic Sea. It formed the German Empire under Prussian rule when it united the German states in 1871. It was ''de facto'' dissolved by an em ...

Province of Lower Silesia The Province of Lower Silesia (german: Provinz Niederschlesien; Silesian German: ''Provinz Niederschläsing''; pl, Prowincja Dolny Śląsk; szl, Prowincyjŏ Dolny Ślōnsk) was a province of the Free State of Prussia from 1919 to 1945. Between ...

, then located in eastern Germany. In January 1945 his family fled from native Silesia to

Dresden Dresden (, ; Upper Saxon: ''Dräsdn''; wen, label=Upper Sorbian, Drježdźany) is the capital city of the German state of Saxony and its second most populous city, after Leipzig. It is the 12th most populous city of Germany, the fourth larg ...

to escape from the advancing

Red Army The Workers' and Peasants' Red Army (Russian: Рабо́че-крестья́нская Кра́сная армия),) often shortened to the Red Army, was the army and air force of the Russian Soviet Federative Socialist Republic and, after ...

. During the

bombing of Dresden The bombing of Dresden was a joint British and American aerial bombing attack on the city of Dresden, the capital of the German state of Saxony, during World War II. In four raids between 13 and 15 February 1945, 772 heavy bombers of the Roya ...

, Blobel, then 8, stayed with his family at a relative's farm to the west of the city. After the war, Blobel grew up and attended gymnasium in the

Saxon The Saxons ( la, Saxones, german: Sachsen, ang, Seaxan, osx, Sahson, nds, Sassen, nl, Saksen) were a group of Germanic * * * * peoples whose name was given in the early Middle Ages to a large country (Old Saxony, la, Saxonia) near the Nor ...

town of

Freiberg Freiberg is a university and former mining town in Saxony, Germany. It is a so-called ''Große Kreisstadt'' (large county town) and the administrative centre of Mittelsachsen district. Its historic town centre has been placed under heritage c ...

. He studied medicine and graduated from the

University of Tübingen The University of Tübingen, officially the Eberhard Karl University of Tübingen (german: Eberhard Karls Universität Tübingen; la, Universitas Eberhardina Carolina), is a public research university located in the city of Tübingen, Baden-Wü ...

in 1960. After two years service in a medical internship, he moved to Madison, Wisconsin, following an older brother, enrolling in the

University of Wisconsin–Madison A university () is an educational institution, institution of higher education, higher (or Tertiary education, tertiary) education and research which awards academic degrees in several Discipline (academia), academic disciplines. Universities ty ...

and, joining the lab of Van R. Potter for his graduate work. Blobel matriculated in 1967 with a Ph.D. He then moved to Rockefeller University as a postdoctoral fellow with George Palade, and was soon appointed as a professor. Blobel was appointed to the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

in 1986. Blobel was the sole recipient of the 1999

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

for the discovery of

signal peptides A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-te ...

. Signal peptides form an integral part of

protein targeting :''This article deals with protein targeting in eukaryotes unless specified otherwise.'' Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the ce ...

, a mechanism for cells to direct newly synthesized

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

molecules to their proper location by means of an "address tag" (i.e., a signal peptide) within the molecule. Blobel died of cancer in

Manhattan Manhattan (), known regionally as the City, is the most densely populated and geographically smallest of the five boroughs of New York City. The borough is also coextensive with New York County, one of the original counties of the U.S. state ...

at New York-Presbyterian Weill Cornell Medical Center on February 18, 2018 at the age of 81. By the time of his death, Blobel was described as having "ushered cell biology into the molecular age" through his work on the fractionation and reconstitution of functional protein complexes and sub-cellular components ''in vitro''.

Philanthropy

Blobel became well known for his direct and active support for the rebuilding of

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

, becoming, in 1994, the founder and president of the nonprofit "Friends of Dresden, Inc." He donated all of the Nobel award money to the restoration of Dresden, in particular for the rebuilding of the Frauenkirche (completed in 2005) and the building of a new

synagogue A synagogue, ', 'house of assembly', or ', "house of prayer"; Yiddish: ''shul'', Ladino: or ' (from synagogue); or ', "community". sometimes referred to as shul, and interchangeably used with the word temple, is a Jewish house of worshi ...

. In Leipzig he pursued a rebuilding of the Paulinerkirche, the university church of the

University of Leipzig Leipzig University (german: Universität Leipzig), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 Decemb ...

, which had been blown up by the communist regime of East Germany in 1968, arguing "this is a shrine of German cultural history, connected to the most important names in German cultural history." Gunter was also a founding member of the board of directors of Research Foundation to Cure AIDS, a U.S. not-for-profit research organization.

Personal life

Blobel lost his older sister to aerial bombing of a train she was on in 1945, shortly after the bombing of Dresden, while an older brother survived the war and became a veterinarian in the United States. Blobel worked at the

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

New York City New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the L ...

from 1968. He lived in

Upper East Side The Upper East Side, sometimes abbreviated UES, is a neighborhood in the borough of Manhattan in New York City, bounded by 96th Street to the north, the East River to the east, 59th Street to the south, and Central Park/Fifth Avenue to the wes ...

with his wife, Laura Maioglio (owner of Barbetta). He was on the board of directors for

Nestlé Nestlé S.A. (; ; ) is a Switzerland, Swiss multinational food and drink processing conglomerate corporation headquartered in Vevey, Vaud, Switzerland. It is the largest publicly held food company in the world, measured by revenue and other me ...

and the Board of Scientific Governors at

The Scripps Research Institute Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institu ...

. Furthermore, he was Co-Founder and Chairman of the Scientific Advisory Board for Chromocell Corporation. He sat on the Selection Committee for Life Science and Medicine which chooses winners of the

Shaw Prize The Shaw Prize is an annual award presented by the Shaw Prize Foundation. Established in 2002 in Hong Kong, it honours "individuals who are currently active in their respective fields and who have recently achieved distinguished and signifi ...

. Blobel had a passion for opera and architecture, in addition to his passion for experimental science.

Scientific awards

* 1978:

NAS Award in Molecular Biology The NAS Award in Molecular Biology is awarded by the U.S. National Academy of Sciences "for recent notable discovery in molecular biology by a young scientist who is a citizen of the United States." It has been awarded annually since its inceptio ...

* 1982:

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a p ...

* 1983:

Otto Warburg Medal The Otto Warburg Medal is awarded annually by the German Society for Biochemistry and Molecular Biology (German: ''Gesellschaft für Biochemie und Molekularbiologie'' or ''GBM'') to honour scientists who have contributed important work in the field ...

* 1983:

Richard Lounsbery Award The Richard Lounsbery Award is given to American and French scientists, 45 years or younger, in recognition of "extraordinary scientific achievement in biology and medicine." The Award alternates between French and American scientists, and is aw ...

* 1983: Member of the

German Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded ...

* Member of the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

* 1984: Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

* 1986:

V. D. Mattia Award ''V.'' is the debut novel of Thomas Pynchon, published in 1963. It describes the exploits of a discharged U.S. Navy sailor named Benny Profane, his reconnection in New York with a group of pseudo-bohemian artists and hangers-on known as the Wh ...

* 1986:

E.B. Wilson Medal The E.B. Wilson Medal is the American Society for Cell Biology's highest honor for science and is presented at the Annual Meeting of the Society for significant and far-reaching contributions to cell biology over the course of a career. It is name ...

* 1986: Keith R. Porter Lecture * 1987:

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

* 1989: Waterford Bio-Medical Science Award * 1989: Member of the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

* 1992:

Max Delbrück Medal The Max Delbrück Medal has been awarded annually from 1992 to 2013 by the Max Delbrück Center for Molecular Medicine (German: ''Max-Delbrück-Centrum für Molekulare Medizin'' or MDC). Named after the German biophysicist Max Delbrück, it is pre ...

* 1993:

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

* 1995:

Ciba Drew Award in Biomedical Research The Novartis-Drew Award for Biomedical Research is an award jointly presented by Novartis and Drew University. It comprises a cash award (originally $2000) and a plaque. The award was initially created as the Ciba-Drew Award for Biomedical Research ...

* 1996:

King Faisal International Prize The King Faisal Prize ( ar, جائزة الملك فيصل, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". T ...

* 1997:

Mayor's Award for Excellence in Science and Technology The Mayor's Award for Excellence in Science and Technology is given annually to recognise important members of the science and engineering communities in New York City. Candidates must live or work in the city. Nominations are submitted in five ca ...

* 1999:

Massry Prize The Massry Prize was established in 1996, and until 2009 was administered by the Meira and Shaul G. Massry Foundation. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in ...

from the

Keck School of Medicine The Keck School of Medicine of the University of Southern California teaches and trains physicians, biomedical scientists and other healthcare professionals, conducts medical research, and treats patients. Founded in 1885, it is the second oldest ...

University of Southern California The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in C ...

* 1999:

* 2001:

Pontifical Academy of Sciences The Pontifical Academy of Sciences ( it, Pontificia accademia delle scienze, la, Pontificia Academia Scientiarum) is a scientific academy of the Vatican City, established in 1936 by Pope Pius XI. Its aim is to promote the progress of the math ...

* 2001:

Pour le Mérite The ' (; , ) is an order of merit (german: Verdienstorden) established in 1740 by Frederick the Great, King Frederick II of Prussia. The was awarded as both a military and civil honour and ranked, along with the Order of the Black Eagle, the Or ...

* 2008: Foreign Member of the

Russian Academy of Science The Russian Academy of Sciences (RAS; russian: Росси́йская акаде́мия нау́к (РАН) ''Rossíyskaya akadémiya naúk'') consists of the national academy of Russia; a network of scientific research institutes from across t ...

* 2014: AACR Academy

References

External links