Free fatty acid receptor 3 (FFA3) is a
G-protein coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
that in humans is encoded by the ''FFAR3''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Animal studies
Knockout mouse studies have implicated FFAR3 in diabetes, colitis, hypertension and asthma. However, discrepancies between the pathways activated by FFAR3 agonists in human cells and the equivalent murine counterparts have been observed.
Heteromerization
FFAR3 may interact with
FFAR2
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the ''FFAR2'' gene.
Expression
''FFAR2'' mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. ''FFAR2 ...
to form a
FFAR2-FFAR3 receptor heteromer
The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.
Signal transduction
The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent re ...
with signalling that is distinct from the parent homomers.
See also
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Free fatty acid receptor
The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids. There are four variants of the receptor, each encoded by a separate gene ( FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FF ...
References
Further reading
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G protein-coupled receptors
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