The free fatty acid receptor is a
G-protein coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of protein family, evolution ...
which binds
free fatty acids
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, f ...
.
There are four variants of the receptor, each encoded by a separate gene (
FFAR1,
FFAR2
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the ''FFAR2'' gene.
Expression
''FFAR2'' mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. ''FFAR2 ...
,
FFAR3
Free fatty acid receptor 3 (FFA3) is a G-protein coupled receptor that in humans is encoded by the ''FFAR3'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity.. ...
,
FFAR4). Preliminary findings suggest that
FFAR2
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the ''FFAR2'' gene.
Expression
''FFAR2'' mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. ''FFAR2 ...
and
FFAR3
Free fatty acid receptor 3 (FFA3) is a G-protein coupled receptor that in humans is encoded by the ''FFAR3'' gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity.. ...
may interact to form a
FFAR2-FFAR3 receptor heteromer
The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.
Signal transduction
The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent re ...
.
References
External links
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G protein-coupled receptors
{{transmembranereceptor-stub