Centre Etude Polymorphisme Humain Institut Genetique Moleculaire Paris France

The Fondation Jean Dausset-CEPH or CEPH, formerly the Centre d'Etude du Polymorphisme Humain (the ''Center for the Study of Human Polymorphisms''), is an international genetic research center located in

Paris Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. Si ...

France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...

. It produced a map that includes genetic markers of human

chromosomes A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins ar ...

using a resource of immortalised cell cultures.

Background

In his 2005 addendum to his biography for the 1980

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

, Jean Dausset noted that, thanks to his Nobel Prize and a grant from the French Téléthon, he had been able in 1984 to create the Human Polymorphism Study Centre (CEPH), which soon after became Foundation Jean Dausset-CEPH. Dausset founded CEPH with the collaboration of Professors Howard Cann and Daniel Cohen. The scientific director of CEPH is currently

Jean-François Deleuze Jean-François is a French given name. Notable people bearing the given name include: * Jean-François Carenco (born 1952), French politician * Jean-François Champollion (1790–1832), French Egyptologist * Jean-François Clervoy (born 1958), ...

and its president is

François d'Aubert François d'Aubert (born 31 October 1943, in Boulogne-Billancourt) is a French politician. He is an auditor at the Court of Audit. From 2002, he was minister delegate to research in Jean-Pierre Raffarin Jean-Pierre Raffarin (; born 3 Augu ...

, a French politician, an auditor at the Cour des Comptes and a former minister delegate to research.

Human genome

Numerous collaborators working on the same large families as Dausset had collected for his Nobel Prize-winning studies on the

human leukocyte antigen The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of th ...

system, led to the addition of numerous gene markers and made it feasible to publish the first

genetic map Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two genetic markers that are physically near to each other are unlikely to be sep ...

and, later on, the first

physical map A map is a symbolic depiction emphasizing relationships between elements of some space, such as objects Object may refer to: General meanings * Object (philosophy), a thing, being, or concept ** Object (abstract), an object which does ...

of the

human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the ...

New resources

An exhaustive study of human populations around the world has also produced important publications from CEPH. Besides this, DNA samples from sibships of people over 95 years old and a bank of

centenarian A centenarian is a person who has reached the age of 100 years. Because life expectancies worldwide are below 100 years, the term is invariably associated with longevity. In 2012, the United Nations estimated that there were 316,600 living centen ...

s now provide a valuable research resource at the Foundation Jean Dausset-CEPH.

References

External links

* {{authority control Genetics or genomics research institutions Research institutes in France