TPSA may refer to:
*Theoretical Physics Student Association, a student-led organisation founded to enhance the academic success of students of theoretical physics.
*Orange Polska, a Polish national telecommunications provider.
*Polar surface area, Topological polar surface area, a physicochemical property describing the polarity of molecules
*Third-party security assessment, an assessment of a third-party's security posture, or alternatively, a security assessment performed by a third-party entity
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