HMB may refer to:

Compounds

* beta-Hydroxy beta-methylbutyric acid, β-Hydroxy β-methylbutyric acid, , a metabolite of the essential amino acid leucine, synthesized in the human body *Human Melanoma Black, a monoclonal antibody

Languages

* Humburi Senni language, spoken in Burkina Faso and Mali

Places

* Half Moon Bay, California, city in the United States

Sports

* Historical medieval battles, a modern sport

Other

* Hawkeye Marching Band, the marching band for the University of Iowa * HabibMetro, a Swiss multinational bank in Pakistan * Heavy menstrual bleeding, a menstrual condition * Host Memory Buffer, an optional feature in version 1.2 of the NVM_Express, NVMe specification, which allows SSDs to utilize the DRAM of the host machine * His/Her Magesty's Barque {{disambiguation