ARDB also known as Antibiotic Resistance Genes Database is a
database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases s ...
that tracks
antibiotic resistance gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
s with information such as
mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targ ...
, resistance profile,
ontology
In metaphysics, ontology is the philosophical study of being, as well as related concepts such as existence, becoming, and reality.
Ontology addresses questions like how entities are grouped into categories and which of these entities exi ...
, Clusters of Orthologous Genes (COG) and
Conserved Domain Database
The Conserved Domain Database (CDD) is a database of well-annotated multiple sequence alignment models and derived database search models, for ancient domains and full-length proteins.
Philosophy
Domains can be thought of as distinct functional ...
(CDD) annotations.
It also contains links to external databases. The database is also for the identification of new
resistance genes. During the creation of ARDB in 2009, there was no comprehensive annotation system available. Thus,
ontology
In metaphysics, ontology is the philosophical study of being, as well as related concepts such as existence, becoming, and reality.
Ontology addresses questions like how entities are grouped into categories and which of these entities exi ...
terms for resistance profiles and
mechanisms of actions were created for ARDB. Other things classified by
ontology
In metaphysics, ontology is the philosophical study of being, as well as related concepts such as existence, becoming, and reality.
Ontology addresses questions like how entities are grouped into categories and which of these entities exi ...
include drug target modification, drug enzymatic destruction and
drug transport.
Drug transporters are further subclassified by
MFS Efflux pumps,
SMR Efflux pumps,
ABC Efflux pumps,
RND Efflux pumps following conventions outlined in this paper.
Currently, ARDB contains resistance information for 13,293
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
s, 377 types, 257
antibiotics, 632
genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding g ...
s, 933
species
In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...
and 124
genera.
ARDB is no longer maintained. All ARDB data are in
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, which the developers now recommend instead.
See also
*
Antimicrobial Resistance databases
References
{{Reflist
Antimicrobial resistance organizations
Biological databases
