Ferid Murad (born September 14, 1936) is an American

physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...

and

pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemic ...

, and a co-winner of the 1998

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

Early life

Murad was born in

Whiting, Indiana Whiting is a city located in the Chicago Metropolitan Area in Lake County, Indiana, which was founded in 1889. The city is located on the southern shore of Lake Michigan. It is roughly 16 miles from the Chicago Loop and two miles from Chicago' ...

. His parents were Henrietta Josephine Bowman of

Alton, Illinois Alton ( ) is a city on the Mississippi River in Madison County, Illinois, Madison County, Illinois, United States, about north of St. Louis, St. Louis, Missouri. The population was 25,676 at the 2020 United States Census, 2020 census. It is a p ...

and Xhabir Murat Ejupi, an

Albania Albania ( ; sq, Shqipëri or ), or , also or . officially the Republic of Albania ( sq, Republika e Shqipërisë), is a country in Southeastern Europe. It is located on the Adriatic and Ionian Seas within the Mediterranean Sea and shares ...

n immigrant from

Gostivar Gostivar ( mk, Гостивар , Albanian and Turkish: ''Gostivar''), is a city in North Macedonia, located in the upper Polog valley region. It is one of the largest municipalities in the country with a population of 81,042, and the town also ...

in present-day

North Macedonia North Macedonia, ; sq, Maqedonia e Veriut, (Macedonia before February 2019), officially the Republic of North Macedonia,, is a country in Southeast Europe. It gained independence in 1991 as one of the successor states of Yugoslavia. It ...

. who subsequently changed his name to John Murad after being processed at

Ellis Island Ellis Island is a federally owned island in New York Harbor, situated within the U.S. states of New York and New Jersey, that was the busiest immigrant inspection and processing station in the United States. From 1892 to 1954, nearly 12 mil ...

in 1913. His mother was from a

Baptist Baptists form a major branch of Protestantism distinguished by baptizing professing Christian believers only ( believer's baptism), and doing so by complete immersion. Baptist churches also generally subscribe to the doctrines of soul compe ...

family and ran away from home in 1935, aged 17, to marry his father, who was 39 and Muslim. Murad is the oldest of three boys; his brothers are John Abderhaman and Turhon Allen. Murad and his brothers were raised as Catholics. He was later baptized an Episcopalian while in college. The family owned a small restaurant while Murad was growing up, and he spent his youth working at the family business. In the eighth grade, he was asked to write an essay of his top three career choices, which he indicated as physician, teacher and pharmacist (in 1948, clinical pharmacology was not yet a discipline in medicine). As of today, he is a board-certified physician and internist doing both basic and clinical research with considerable teaching in medicine, pharmacology and clinical pharmacology and with a PhD in pharmacology.

Education

Murad competed successfully for a Rector Scholarship at

DePauw University DePauw University is a private liberal arts university in Greencastle, Indiana. It has an enrollment of 1,972 students. The school has a Methodist heritage and was originally known as Indiana Asbury University. DePauw is a member of both the ...

Greencastle, Indiana Greencastle is a city in Greencastle Township, Putnam County, Indiana, United States, and the county seat of Putnam County. It was founded in 1821 by Ephraim Dukes on a land grant. He named the settlement for his hometown of Greencastle, Pennsylv ...

, a small and excellent liberal arts university on a tuition scholarship. He received his undergraduate degree in chemistry from the

pre-med Pre-medical (often referred to as pre-med) is an educational track that undergraduate students in the United States pursue prior to becoming medical students. It involves activities that prepare a student for medical school, such as pre-med course ...

program at

in 1958. During his senior year of college he began to apply to medical schools when his faculty advisor Forst Fuller, a professor in the biology department suggested that he consider a new MD-PhD program at Case Western Reserve University. A fraternity brother, Bill Sutherland, also advised that he consider this new combined degree program that his father

Earl Sutherland, Jr Earl Wilbur Sutherland Jr. (November 19, 1915 – March 9, 1974) was an American pharmacologist and biochemist born in Burlingame, Kansas. Sutherland won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanis ...

initiated in Cleveland in 1957. The program paid full tuition for both degrees and provided a modest stipend of $2,000 per year. Murad ultimately decided to attend and became an early graduate of the first explicit MD and pharmacology

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

program (which would later lead to the development of the prestigious

Medical Scientist Training Program The Medical Scientist Training Programs (MSTPs) are dual-degree training programs that streamline the education towards both clinical (typically MD) and research doctoral degrees. MSTPs are offered by some United States medical schools, who are aw ...

) obtaining his degrees from Case Western Reserve University in 1965. He was an Intern in Internal Medicine at Massachusetts General Hospital (1965–66), Resident in Internal Medicine (1966–67), Clinical Associate and Senior Assistant Surgeon, Public Health Service,

National Heart and Lung Institute The Faculty of Medicine is the academic centre for medical and clinical research and teaching at Imperial College London. It contains the Imperial College School of Medicine, which is the college's undergraduate medical school. History Medica ...

(1967–69) and Senior Staff Fellow there from 1969–70.

Career

He began his academic career by joining the

University of Virginia The University of Virginia (UVA) is a public research university in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, the university is ranked among the top academic institutions in the United States, with highly selective ad ...

, where he was made associate professor, Depts. of Internal Medicine and Pharmacology, School of Medicine in 1970, before becoming a full professor in 1975. From 1971–81 he was Director, Clinical Research Center, UVA School of Medicine and Director, Division of Clinical Pharmacology, Dept. of Internal Medicine, UVA School of Medicine (1973–81). Murad moved to Stanford University in 1981 where he was Chief of Medicine at the Palo Alto VA Medical Center (1981–86), Associate Chairman, Dept. of Medicine, Stanford University (1984–86), and Acting Chairman, Dept. of Medicine and Acting Division Chief, Division of Respiratory Medicine from 1986–88. In 1988 he was the American Heart Association, Ciba Award Recipient. Murad left his tenure at Stanford in 1988 for a position at Abbott Laboratories, where he served as a Vice President of Pharmaceutical Discovery until founding his own biotechnology company, the Molecular Geriatrics Corporation, in 1993. Murad went back to academics and joined the

University of Texas Medical School at Houston The University of Texas Health Science Center at Houston (UTHealth) is a public academic health science center in Houston, Texas, United States. It was created in 1972 by The University of Texas System Board of Regents. It is located in the T ...

to create a new department of integrative biology, pharmacology, and physiology in 1997. There, he was the chairman of Integrative Biology and Pharmacology, professor and director emeritus of The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Disease, John S. Dunn Distinguished Chair in Physiology and Medicine, deputy director of The Brown Foundation Institute of Molecular Medicine, and later a professor at the Brown Foundation Institute of Molecular Medicine. In April 2011, he moved to the

George Washington University The George Washington University (GW or GWU) is a Private university, private University charter#Federal, federally chartered research university in Washington, D.C. Chartered in 1821 by the United States Congress, GWU is the largest Higher educat ...

as a professor in the Department of Biochemistry and Molecular Biology. Murad's key research demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. The missing steps in the signaling process were filled in by

Robert F. Furchgott Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems. Early life and education Furchgott ...

and Louis J. Ignarro of

UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California ...

, for which the three shared the 1998 Nobel Prize (and for which Murad and Furchgott received the Albert Lasker Award for Basic Medical Research in 1996). In 1999, Murad and Furchgott received the Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...

. He is also a member of the National Academy of Sciences among other notable societies. In 2015, Murad signed the

Mainau Declaration The Mainau Declaration is either of two socio-political appeals by Nobel laureates who participated in the Lindau Nobel Laureate Meetings, the annual gathering with young scientists at the German town of Lindau. The name denotes that these declar ...

2015 on Climate Change on the final day of the 65th Lindau Nobel Laureate Meeting. The declaration was signed by a total of 76 Nobel Laureates and handed to then-President of the French Republic, François Hollande, as part of the successful COP21 climate summit in Paris. Prof. Murad is now editing a book series published by Bentham Science Publishers titled ''Herbal medicine: Back to the Future''; two volumes of which have already been published and a third volume is in preparation.

Awards and recognitions

* Albert Lasker Award for Basic Medical Research *

* American Heart Association, Ciba Award * National Academy of Sciences *

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

References

External links