Fabomotizole ( INN; brand name Afobazole) is an anxiolytic

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhala ...

launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3

receptor antagonism A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of rec ...

, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with

serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and va ...

receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have shown antimutagenic and antiteratogenic properties. Fabomotizole has found little clinical use outside Russia and has not been evaluated by the FDA.

References

{{Sigma receptor modulators Anxiolytics Drugs with unknown mechanisms of action 4-Morpholinyl compunds Thioethers Benzimidazoles Phenol ethers Russian drugs Melatonin receptor antagonists Monoamine oxidase inhibitors Sigma agonists

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