FG-8205 (L-663,581) is an imidazobenzodiazepine derivative related to bretazenil, which acts as a

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

at GABA_A receptors, with slight selectivity for the α₁-containing subtype. In animal tests it has

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

and anticonvulsant effects but with little sedation or ataxia produced.

References

GABAA receptor positive allosteric modulators Imidazobenzodiazepines Oxadiazoles Isopropyl compounds {{nervous-system-drug-stub

See also

References