High affinity immunoglobulin gamma Fc receptor I is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''FCGR1A''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Interactions
The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.
[The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 , VOLUME 14 Nature Reviews Immunology]
References
Further reading
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External links
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Fc receptors
{{immunology-stub