Euphratensis (Latin for "Euphratean"; Greek: Εὑφρατησία, Euphratēsía), fully Augusta Euphratensis, was a late Roman and then Byzantine province in Syrian region, part of the Byzantine Diocese of the East.
Sometime between 330 and 350 (likely c. 341), the Roman province of Euphratensis was created out of the territory of Syria Coele along the western bank of the Euphrates. It included the territories of Commagene and Cyrrhestice. Its capital was Cyrrus or perhaps Hierapolis Bambyce. It remained within the Byzantine Empire following the 395 division of the empire by Theodosius I.