Eukaryotic translation initiation factor 2-alpha kinase 4 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
that in humans is encoded by the ''EIF2AK4''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
EIF2AK4 belongs to a family of kinases that
phosphorylate
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, ...
the alpha subunit of eukaryotic translation initiation factor-2 (
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the ''EIF2S1'' gene.
Function
The protein encoded by this gene is the alpha (α) subunit of the translation initiation factor eIF2 prote ...
; MIM 603907) to downregulate
protein synthesis
Protein biosynthesis (or protein synthesis) is a core biological process, occurring inside cells, balancing the loss of cellular proteins (via degradation or export) through the production of new proteins. Proteins perform a number of critical ...
in response to varied cellular stresses (Berlanga et al., 1999).
upplied by OMIMref name="entrez"/>
See also
*
Gcn2
GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that senses amino acid deficiency through binding to uncharged transfer RNA (tRNA). It plays a key role in modulating amino acid metabolism as a response to nutrient d ...
References
Further reading
*
*
*
*
*
*
*
*
External links
*
EC 2.7.11
{{gene-15-stub