The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
s (GPCRs). These receptors have a unique hybrid structure in which an extracellular
epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a
mucin
Mucins () are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most ...
-like stalk.
There are four variants of EMR labeled 1-4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as
CD55.
References
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G protein-coupled receptors
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