EA-3148 (Substance 100A) is a "V-series"

nerve agent Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that ...

related to the better-known compounds VX and VR. It was studied by both the US and Soviet chemical weapons programmes during the Cold War, and is notable as the only V-series organophosphate nerve agent specifically identified in public domain sources as having a higher absolute potency as an acetylcholinesterase inhibitor than VX (around 50% more potent by weight). However, both the US and Soviet investigations of the compound concluded that despite its high potency, the physicochemical properties of the substance made it unsuitable for weaponisation, and further research was not conducted. The chemical structure of EA-3148 falls within the scope of compounds designated "Toxic chemicals" under

Schedule 1 Schedule 1 may refer to: * Schedule I Controlled Substances within the US Controlled Substances Act * Schedule I Controlled Drugs and Substances within the Canadian Controlled Drugs and Substances Act * Schedule I Psychotropic Substances within t ...

of the Chemical Weapons Convention and so it is illegal throughout the world under

international law International law (also known as public international law and the law of nations) is the set of rules, norms, and standards generally recognized as binding between states. It establishes normative guidelines and a common conceptual framework for ...

and may only be used for certain types of scientific and medical research.

Effects

A healthy American male soldier was given EA-3148, 1.15 µg/kg i.v..

Erythrocyte Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "holl ...

AChE values dropped precipitously to 22% of normal within 15 min of dosing and to 0% at 48 h; the value recovered to 88% of normal at 72 days post-exposure. Signs of toxicity were evident within 5-8 min of treatment in two comparably dosed subjects who felt dizzy, weak, tired, sweaty, and had hands and feet that were moist. Within 2 h post-exposure, these subjects reportedly were resting, eating, and feeling fine. A

U.S. Army The United States Army (USA) is the land service branch of the United States Armed Forces. It is one of the eight U.S. uniformed services, and is designated as the Army of the United States in the U.S. Constitution.Article II, section 2, cl ...

report summarizing experience with EA-3148 noted anorexia, fatigue, poor sleep, unusual dreams, dizziness, euphoria, blurred vision, increased salivation, restlessness; decrements in a test of numerical facility in four individuals and exaggeration of a schizoid personality in one male soldier.Barry W. Wilson, Ph.D.. Low-Level Sarion Neurotoxicity and its Modulation by Pyridostigmine. University of California Davis, California.

References

{{Acetylcholine metabolism and transport modulators Acetylcholinesterase inhibitors V-series nerve agents Phosphonothioates Chemical weapons Cyclopentanes Diethylamino compounds