Doxefazepam
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Doxefazepam (marketed under brand name Doxans) is a benzodiazepine medication It possesses
anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
, anticonvulsant, sedative and
skeletal muscle relaxant A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeu ...
properties. It is used therapeutically as a hypnotic. According to Babbini and colleagues in 1975, this derivative of
flurazepam Flurazepam (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite w ...
was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals. It was patented in 1972 and came into medical use in 1984.


Side effects

Section 5.5 of the article ''Doxefazepam'' in volume 66 of the World Health Organization's (WHO) and International Agency for Research on Cancer's (IARC) ''IARC Monographs On The Evaluation Of Carcinogenic Risks To Humans'', an article describing the carcinogenic/toxic effects of doxefazepam on humans and experimental animals, states that there is "inadequate evidence in humans for the
carcinogen A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive subs ...
icity of doxefazepam" and limited evidence in experimental for the carcinogenicity of doxefazepam," and concluded that the overall evaluation of the substance's carcinogenicity to humans is "not classifiable."


See also

* Benzodiazepine


References


External links


Inchem.org - Doxefazepam

IARC Monographs - Doxefazepam
Primary alcohols Lactims Benzodiazepines Chloroarenes Fluoroarenes Hypnotics Lactams {{sedative-stub