5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an
endogenous progestogen and
neurosteroid.
It is synthesized from the
adrenal hormone deoxycorticosterone (DOC) by the
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
5α-reductase type I.
DHDOC is an
agonist of the
progesterone receptor, as well as a
positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
of the
GABAA receptor, and is known to have
anticonvulsant effects.
Chemistry
See also
*
Tetrahydrodeoxycorticosterone (THDOC)
*
5α-Dihydroprogesterone (DHP)
*
Hydroxydione
References
{{GABAAR PAMs
Neurosteroids
Pregnanes
Progestogens
GABAA receptor positive allosteric modulators