Dienolone (developmental code name RU-3118; online product names Trenazone, Dienazone), or nordienolone, also known as 19-nor-δ⁹⁽¹⁰⁾-testosterone, δ⁹⁽¹⁰⁾-nandrolone, or estra-4,9(10)-dien-17β-ol-3-one, is a synthetic

anabolic-androgenic steroid Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects t ...

(AAS) of the 19-nortestosterone group that was never marketed.https://isomerdesign.com/Cdsa/HC/StatusDecisions/A-2013-00235%20-%20PDFs/C-Dienolone-2011-08-12.pdf It has been found to possess slightly lower

affinity Affinity may refer to: Commerce, finance and law * Affinity (law), kinship by marriage * Affinity analysis, a market research and business management technique * Affinity Credit Union, a Saskatchewan-based credit union * Affinity Equity Par ...

for the androgen receptor (AR) and progesterone receptor (PR) relative to

nandrolone Nandrolone, also known as 19-nortestosterone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin) and nandrolone phenylpropionate (brand name Durabolin). Nandrolon ...

in rat and rabbit tissue

bioassay A bioassay is an analytical method to determine the concentration or potency of a substance by its effect on living animals or plants (''in vivo''), or on living cells or tissues(''in vitro''). A bioassay can be either quantal or quantitative, dir ...

s, whereas trenbolone was found to possess the same affinity for the AR as dienolone but several-fold increased affinity for the PR.

Dienedione Dienedione, also known as estra-4,9-diene-3,17-dione, is a synthetic, orally active anabolic-androgenic steroid (AAS) of the 19-nortestosterone group that was never introduced for medical use. It is thought to be a prohormone of dienolone. Th ...

(the 17-keto analogue of dienolone, also known as 19-nor-4,9-androstadienedione) is thought to be a

prohormone A prohormone is a committed precursor of a hormone consisting of peptide hormones synthesized together that has a minimal hormonal effect by itself because of its expression-suppressing structure, often created by protein folding and binding additi ...

of dienolone, while methyldienolone and ethyldienolone are orally active 17α-alkylated AAS derivatives of dienolone. In contrast,

dienogest Dienogest, sold under the brand name Visanne among others, is a progestin medication which is used in birth control pills and in the treatment of endometriosis. It is also used in menopausal hormone therapy and to treat heavy periods. Dienogest ...

, the 17α- cyanomethyl derivative of dienolone, is a potent progestogen and

antiandrogen Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the ...

References

{{Progesterone receptor modulators Androgens and anabolic steroids Conjugated dienes Estranes Enones Progestogens

See also

References