Depression may refer to:

Mental health

* Depression (mood), a state of low mood and aversion to activity * Mood disorders characterized by depression are commonly referred to as simply ''depression'', including: ** Dysthymia, also known as persistent depressive disorder ** Major depressive disorder, also known as clinical depression

Economics

* Economic depression, a sustained, long-term downturn in economic activity in one or more economies ** Great Depression, a severe economic depression during the 1930s, commonly referred to as simply ''the Depression'' ** Long Depression, an economic depression during 1873–96, known at the time as the ''Great Depression''

Biology

* Depression (kinesiology), an anatomical term of motion, refers to downward movement, the opposite of elevation * Depression (physiology), a reduction in a biological variable or the function of an organ * Central nervous system depression, physiological depression of the central nervous system that can result in loss of consciousness

Earth science

* Depression (geology), a landform sunken or depressed below the surrounding area * Depression (weather), an area of low atmospheric pressure characterized by rain and unstable weather {{Disambiguation