David Ezra Green (August 5, 1910 – July 8, 1983) was an American biochemist who made significant contributions to the study of

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

s, particularly the

electron transport chain An electron transport chain (ETC) is a series of protein complexes and other molecules that transfer electrons from electron donors to electron acceptors via redox reactions (both reduction and oxidation occurring simultaneously) and couples ...

and

oxidative phosphorylation Oxidative phosphorylation (UK , US ) or electron transport-linked phosphorylation or terminal oxidation is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing chemical energy in order to produce adenosine t ...

Life and career

Green was born in Brooklyn,

New York New York most commonly refers to: * New York City, the most populous city in the United States, located in the state of New York * New York (state), a state in the northeastern United States New York may also refer to: Film and television * '' ...

, the son of Jennie (Marrow) and Hyman Levy Green, a garment manufacturer. His parents were

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

immigrants from Russia and Germany. He was awarded a degree in biology from

New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then- Secretary of the Treasury Albert Gallatin. In 1832, th ...

. He then moved to England and worked for eight years at the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

under the supervision of Malcolm Dixon, on

redox Redox (reduction–oxidation, , ) is a type of chemical reaction in which the oxidation states of substrate change. Oxidation is the loss of electrons or an increase in the oxidation state, while reduction is the gain of electrons or ...

reactions in biological systems. He received his PhD under Dixon in 1934 with a thesis entitled ''The Application of Oxidation-Reduction Potentials to Biological Systems.'' At the outbreak of the Second World War, Green moved back to America and established himself in a laboratory at

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

. Here he studied the metabolism of

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...

s and the

citric acid cycle The citric acid cycle (CAC)—also known as the Krebs cycle or the TCA cycle (tricarboxylic acid cycle)—is a series of chemical reactions to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and prot ...

. In 1948, Green moved to the

University of Wisconsin–Madison A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United Stat ...

and set up the Institute for Enzyme Research, making vital contributions to studies on oxidative phosphorylation, the electron transport chain and

beta oxidation In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cyc ...

. He was married to English-born Doris Cribb. He is the father of biochemist Rowena Green Matthews and grandfather of Wisconsin Senator

Tammy Baldwin Tammy Suzanne Green Baldwin (born February 11, 1962) is an American lawyer and politician who has served as the junior United States senator from Wisconsin since 2013. A member of the Democratic Party, she served three terms in the Wisconsin St ...

References

External links

National Academy of Sciences Biographical Memoir
American biochemists 1910 births 1983 deaths American people of German-Jewish descent American people of Russian-Jewish descent Jewish American scientists 20th-century American Jews {{US-biochemist-stub