DS-1 is a drug from the
imidazopyridine
An imidazopyridine is a nitrogen containing heterocycle that is also a class of drugs that contain this same chemical substructure. In general, they are GABAA receptor agonists, however recently proton pump inhibitors, aromatase inhibitors, NSA ...
family, which is the first drug developed that acts as a
GABAA receptor positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
(PAM) selective for the
α4 β3 δ subtype, which is not targeted by other GABA
A receptor PAMs such as the
benzodiazepines or other
nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.
See also
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Alpidem
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family, related to the more well known sleeping medication zolpidem. Unlike zolpidem however, alpidem does not produce sedative effects at normal doses, and is instead used specifi ...
*
Saripidem
*
Zolpidem
Zolpidem, sold under the brand name Ambien, among others, is a medication primarily used for the short-term treatment of sleeping problems. Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and behavior ...
References
Benzamides
Chloroarenes
GABAA receptor positive allosteric modulators
Imidazopyridines
Organobromides
Thiophenes
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