Craig Venter
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John Craig Venter (born October 14, 1946) is an American biotechnologist and businessman. He is known for leading one of the first draft sequences of the
human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the ...
and assembled the first team to transfect a cell with a synthetic chromosome. Venter founded
Celera Genomics Celera is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera, spun off into an independent company in 2008, and finally acquired by Quest Diagnost ...
, the Institute for Genomic Research (TIGR) and the J. Craig Venter Institute (JCVI). He was the co-founder of Human Longevity Inc. and Synthetic Genomics. He was listed on ''
Time Time is the continued sequence of existence and event (philosophy), events that occurs in an apparently irreversible process, irreversible succession from the past, through the present, into the future. It is a component quantity of various me ...
'' magazine's 2007 and 2008 ''Time'' 100 list of the most influential people in the world. In 2010, the British magazine ''
New Statesman The ''New Statesman'' is a British political and cultural magazine published in London. Founded as a weekly review of politics and literature on 12 April 1913, it was at first connected with Sidney and Beatrice Webb and other leading members ...
'' listed Craig Venter at 14th in the list of "The World's 50 Most Influential Figures 2010". In 2012, Venter was honored with
Dan David Prize The Dan David Prize is a major international award that recognizes and supports outstanding contributions to the study of history and other disciplines that shed light on the human past. It awards nine prizes of $300,000 each year to outstanding ...
for his contribution to genome research. He was elected to the
American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...
in 2013. He is a member of the
USA Science and Engineering Festival The USA Science & Engineering Festival is a bi-annual science festival held in Washington, D.C. Founded in 2010 by Larry Bock, the festival is the largest celebration of science, technology, engineering, and mathematics (STEM) disciplines in the ...
's advisory board. retrieved 2010-07-05


Early life and education

Venter was born in
Salt Lake City, Utah Salt Lake City (often shortened to Salt Lake and abbreviated as SLC) is the capital and most populous city of Utah, United States. It is the seat of Salt Lake County, the most populous county in Utah. With a population of 200,133 in 2020, t ...
, the son of Elizabeth and John Venter. In his youth, he did not take his education seriously, preferring to spend his time on the water in boats or surfing. According to his biography, ''A Life Decoded'', he was said never to be a terribly engaged student, having Cs and Ds on his eighth-grade report cards. Venter considered that his behavior in his adolescence was indicative of
attention deficit hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inap ...
(ADHD), and later found ADHD-linked genetic variants in his own DNA. He graduated from
Mills High School Mills High School is a public high school in Millbrae, California, one of seven in the San Mateo Union High School District. Mills was established in 1958. Mills High School has been named a California Distinguished School three times (1988, 199 ...
in
Millbrae, California Millbrae is a city located in northern San Mateo County, California, United States. To its northeast is San Francisco International Airport, San Bruno is on its northwest, and Burlingame on its southeast. It is bordered by San Andreas Lake ...
. His father died suddenly at age 59 from cardiac arrest, giving him a lifelong awareness of his own mortality. He quotes a saying: "If you want immortality, do something meaningful with your life." Although he opposed the
Vietnam War The Vietnam War (also known by #Names, other names) was a conflict in Vietnam, Laos, and Cambodia from 1 November 1955 to the fall of Saigon on 30 April 1975. It was the second of the Indochina Wars and was officially fought between North Vie ...
, Venter was drafted and enlisted in the
United States Navy The United States Navy (USN) is the maritime service branch of the United States Armed Forces and one of the eight uniformed services of the United States. It is the largest and most powerful navy in the world, with the estimated tonnage ...
where he worked as a
hospital corpsman A hospital corpsman (HM r corpsman is an enlisted medical specialist of the United States Navy, who may also serve in a U.S. Marine Corps unit. The corresponding rating within the United States Coast Guard is health services technician (HS ...
in the intensive-care ward of a field hospital. He served from 1967 to 1968 at the
Naval Support Activity Danang Naval Support Activity Danang or NSA Danang was a United States Navy logistics support organization located in Danang, South Vietnam active from October 1965 to April 1972. History In March 1965 when United States Marine Corps combat troops land ...
in
Vietnam Vietnam or Viet Nam ( vi, Việt Nam, ), officially the Socialist Republic of Vietnam,., group="n" is a country in Southeast Asia, at the eastern edge of mainland Southeast Asia, with an area of and population of 96 million, making ...
. While in Vietnam, he attempted suicide by swimming out to sea, but changed his mind more than a mile out. Being confronted with severely injured and dying marines on a daily basis instilled in him a desire to study medicine, although he later switched to
biomedical research Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from " basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scienti ...
. Venter began his college education in 1969 at a
community college A community college is a type of educational institution. The term can have different meanings in different countries: many community colleges have an "open enrollment" for students who have graduated from high school (also known as senior s ...
,
College of San Mateo College of San Mateo (CSM) is a public community college in San Mateo, California. It is part of the San Mateo County Community College District. College of San Mateo is located at the northern corridor of Silicon Valley and situated on a 153 ...
in
California California is a state in the Western United States, located along the Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the most populous U.S. state and the 3rd largest by area. It is also the m ...
, and later transferred to the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is ...
, where he studied under biochemist Nathan O. Kaplan. He received a
Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...
in
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
in 1972 and a
Doctor of Philosophy A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...
in
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemic ...
and
pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
in 1975 from UCSD.


Career

After working as an
associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. Overview In the '' North American system'', used in the United States and many other countries, it is ...
, and later as full professor, at the
State University of New York at Buffalo The State University of New York at Buffalo, commonly called the University at Buffalo (UB) and sometimes called SUNY Buffalo, is a public research university with campuses in Buffalo and Amherst, New York. The university was founded in 1846 ...
, he joined the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...
in 1984.


EST controversy

While an employee of the
NIH The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
, Venter learned how to identify
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the ...
and began to learn more about those expressed in the human brain. The short
cDNA In genetics, complementary DNA (cDNA) is DNA synthesized from a single-stranded RNA (e.g., messenger RNA (mRNA) or microRNA (miRNA)) template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA is often used to express a sp ...
sequence fragments he was interested in are called
expressed sequence tag In genetics, an expressed sequence tag (EST) is a short sub-sequence of a cDNA sequence. ESTs may be used to identify gene transcripts, and were instrumental in gene discovery and in gene-sequence determination. The identification of ESTs has proc ...
s, or ESTs. The NIH Office of Technology Transfer and Venter decided to take the ESTs discovered by others in an attempt to patent the genes identified based on studies of
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the ...
expression in the human brain. When Venter disclosed this strategy during a Congressional hearing, a firestorm of controversy erupted. The NIH later stopped the effort and abandoned the patent applications it had filed, following public outcry.


Human Genome Project

Venter was passionate about the power of genomics to transform healthcare radically. Venter believed that
shotgun sequencing In genetics, shotgun sequencing is a method used for sequencing random DNA strands. It is named by analogy with the rapidly expanding, quasi-random shot grouping of a shotgun. The chain-termination method of DNA sequencing ("Sanger sequencing ...
was the fastest and most effective way to get useful human genome data. The method was rejected by the Human Genome Project however, since some geneticists felt it would not be accurate enough for a genome as complicated as that of humans, that it would be logistically more difficult, and that it would cost significantly more. Venter viewed the slow pace of progress in the Human Genome project as an opportunity to continue his interest in patenting genes, so he sought funding from the private sector to start
Celera Genomics Celera is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera, spun off into an independent company in 2008, and finally acquired by Quest Diagnost ...
. The company planned to profit from their work by creating genomic data to which users could subscribe for a fee. The goal consequently put pressure on the public genome program and spurred several groups to redouble their efforts to produce the full sequence. Venter's effort won him renown as he and his team at
Celera Corporation Celera is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera, spun off into an independent company in 2008, and finally acquired by Quest Diagnos ...
shared credit for sequencing the first draft human genome with the publicly funded
Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both ...
. In 2000, Venter and
Francis Collins Francis Sellers Collins (born April 14, 1950) is an American physician-geneticist who discovered the genes associated with a number of diseases and led the Human Genome Project. He is the former director of the National Institutes of Health (N ...
of the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...
and U.S. Public Genome Project jointly made the announcement of the mapping of the human genome, a full three years ahead of the expected end of the Public Genome Program. The announcement was made along with U.S. President
Bill Clinton William Jefferson Clinton (né Blythe III; born August 19, 1946) is an American politician who served as the 42nd president of the United States from 1993 to 2001. He previously served as governor of Arkansas from 1979 to 1981 and again ...
, and
UK Prime Minister The prime minister of the United Kingdom is the head of government of the United Kingdom. The prime minister advises the sovereign on the exercise of much of the royal prerogative, chairs the Cabinet and selects its ministers. As modern pr ...
Tony Blair Sir Anthony Charles Lynton Blair (born 6 May 1953) is a British former politician who served as Prime Minister of the United Kingdom from 1997 to 2007 and Leader of the Labour Party from 1994 to 2007. He previously served as Leader of t ...
. Venter and Collins thus shared an award for "Biography of the Year" from
A&E Network A&E is an American basic cable network, the flagship television property of A&E Networks. The network was originally founded in 1984 as the Arts & Entertainment Network, initially focusing on fine arts, documentaries, dramas, and educational ent ...
." On 15 February 2001, the Human Genome Project consortium published the first Human Genome in the journal ''
Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...
'', followed one day later by a Celera publication in ''
Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence ...
''. Despite some claims that
shotgun sequencing In genetics, shotgun sequencing is a method used for sequencing random DNA strands. It is named by analogy with the rapidly expanding, quasi-random shot grouping of a shotgun. The chain-termination method of DNA sequencing ("Sanger sequencing ...
was in some ways less accurate than the clone-by-clone method chosen by the Human Genome Project, the technique became widely accepted by the scientific community. Venter was fired by Celera in early 2002. According to his biography, Venter was fired because of a conflict with the main investor, Tony White, specifically barring him from attending the White House ceremony celebrating the achievement of sequencing the human genome.


Global Ocean Sampling Expedition

The
Global Ocean Sampling Expedition The Global Ocean Sampling Expedition (GOS) is an ocean exploration genome project whose goal is to assess genetic diversity in marine microbial communities and to understand their role in nature's fundamental processes. It was begun as a Sargass ...
(GOS) is an
ocean exploration Ocean exploration is a part of oceanography describing the exploration of ocean surfaces. Notable explorations were undertaken by the Greeks, the Romans, the Polynesians, the Phoenicians, Phytheas, Herodotus, the Vikings, the Portuguese and ...
genome project Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes ...
with the goal of assessing the
genetic diversity Genetic diversity is the total number of genetic characteristics in the genetic makeup of a species, it ranges widely from the number of species to differences within species and can be attributed to the span of survival for a species. It is dis ...
in
marine Marine is an adjective meaning of or pertaining to the sea or ocean. Marine or marines may refer to: Ocean * Maritime (disambiguation) * Marine art * Marine biology * Marine debris * Marine habitats * Marine life * Marine pollution Military ...
microbial communities Microbial population biology is the application of the principles of population biology to microorganisms. Distinguishing from other biological disciplines Microbial population biology, in practice, is the application of population ecology and popu ...
and to understand their role in nature's fundamental processes. Begun as a Sargasso Sea pilot sampling project in August 2003, Venter announced the full Expedition on 4 March 2004. The project, which used Venter's personal yacht, ''Sorcerer II'', started in Halifax, Canada, circumnavigated the globe and returned to the U.S. in January 2006.


Synthetic Genomics

In June 2005, Venter co-founded Synthetic Genomics, a firm dedicated to using modified
microorganisms A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...
to produce
clean fuels Clean fuel may refer to type of fuel used for transport or a type of fuel used for cooking and lighting. With regards to cooking, the Sustainable Development Goal 7 aims to "Ensure access to affordable, reliable, sustainable and modern energy for a ...
and biochemicals. In July 2009,
ExxonMobil ExxonMobil Corporation (commonly shortened to Exxon) is an American multinational oil and gas corporation headquartered in Irving, Texas. It is the largest direct descendant of John D. Rockefeller's Standard Oil, and was formed on November 3 ...
announced a $600 million collaboration with Synthetic Genomics to research and develop next-generation
biofuel Biofuel is a fuel that is produced over a short time span from biomass, rather than by the very slow natural processes involved in the formation of fossil fuels, such as oil. According to the United States Energy Information Administration ...
s. Venter continues to work on the creation of engineered diatomic microalgae for the production of biofuels. Venter is seeking to patent the first partially synthetic species possibly to be named ''
Mycoplasma laboratorium ''Mycoplasma laboratorium'' or Synthia refers to a synthetic strain of bacterium. The project to build the new bacterium has evolved since its inception. Initially the goal was to identify a minimal set of genes that are required to sustain lif ...
''. There is speculation that this line of research could lead to producing bacteria that have been engineered to perform specific reactions, for example, produce
fuels A fuel is any material that can be made to react with other substances so that it releases energy as thermal energy or to be used for work. The concept was originally applied solely to those materials capable of releasing chemical energy but ...
, make
medicines A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the medical field and re ...
, combat
global warming In common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to ...
, and so on. In May 2010, a team of scientists led by Venter became the first to create successfully what was described as "
synthetic life Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad ran ...
". This was done by synthesizing a very long DNA molecule containing an entire bacterium
genome In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding ...
, and introducing this into another
cell Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery ...
, analogous to the accomplishment of
Eckard Wimmer Eckard Wimmer (born 22 May 1936) is a German American virologist, organic chemist and distinguished professor of molecular genetics and microbiology at Stony Brook University. He is best known for his seminal work on the molecular biology of p ...
's group, who synthesized and ligated an
RNA virus An RNA virus is a virusother than a retrovirusthat has ribonucleic acid ( RNA) as its genetic material. The nucleic acid is usually single-stranded RNA (ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA virus ...
genome and "booted" it in cell lysate. The single-celled organism contains four "watermarks" written into its DNA to identify it as synthetic and to help trace its descendants. The watermarks include # Code table for entire alphabet with punctuations # Names of 46 contributing scientists # Three quotations # The secret email address for the cell. On March 25, 2016, Venter reported the creation of Syn 3.0, a synthetic genome having the fewest genes of any freely living organism (473 genes). Their aim was to strip away all nonessential genes, leaving only the minimal set necessary to support life. This stripped-down, fast reproducing cell is expected to be a valuable tool for researchers in the field. In August 2018, Venter retired as chairman of the board, saying he wanted to focus on his work at the J. Craig Venter Institute. He will remain as a scientific advisor to the board.


J. Craig Venter Institute

In 2006 Venter founded the J. Craig Venter Institute (JCVI), a nonprofit which conducts research in
synthetic biology Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad ran ...
. It has facilities in La Jolla and in
Rockville, Maryland Rockville is a city that serves as the county seat of Montgomery County, Maryland, and is part of the Baltimore–Washington metropolitan area. The 2020 census tabulated Rockville's population at 67,117, making it the fifth-largest community in ...
and employs over 200 people. In April 2022 Venter sold the La Jolla JCVI facility to the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is ...
for $25 million. The university, which already has a very strong genomics program, hopes to absorb most of the Institute's faculty and its current research grants. Venter will continue to lead a separate nonprofit research group, also known as the J. Craig Venter Institute, and stressed that he is not retiring.


Individual human genome

On September 4, 2007, a team led by Sam Levy published one of the first genomes of an individual human—Venter's own DNA sequence. Some of the sequences in Venter's genome are associated with wet earwax, increased risk of antisocial behavior,
Alzheimer's Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As t ...
and
cardiovascular diseases Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, ...
. This publication was especially interesting because it attempted to separate the two
haplotypes A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. Many organisms contain genetic material ( DNA) which is inherited from two parents. Normally these organisms have their DNA org ...
(the two copies of each chromosome), although it only accomplished this in a limited way. The genome as published only had 3 billion bases, rather than the full 6 billion that would compose a fully diploid sequence. Another 10 years passed before the first haplotype-resolved human genomes began to appear. The Human Reference Genome Browser is a web application for the navigation and analysis of Venter's recently published genome. The HuRef database consists of approximately 32 million DNA reads sequenced using
microfluidic Sanger sequencing Sanger sequencing is a method of DNA sequencing that involves electrophoresis and is based on the random incorporation of chain-terminating dideoxynucleotides by DNA polymerase during in vitro DNA replication. After first being developed by Frederi ...
, assembled into 4,528 scaffolds and 4.1 million DNA variations identified by genome analysis. These variants include
single-nucleotide polymorphism In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently ...
s (SNPs), block substitutions, short and large
indel Indel is a molecular biology term for an insertion or deletion of bases in the genome of an organism. It is classified among small genetic variations, measuring from 1 to 10 000 base pairs in length, including insertion and deletion events that ...
s, and structural variations like insertions, deletions, inversions and copy number changes. The browser enables scientists to navigate the HuRef genome assembly and sequence variations, and to compare it with the NCBI human build 36 assembly in the context of the NCBI and
Ensembl Ensembl genome database project is a scientific project at the European Bioinformatics Institute, which provides a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other v ...
annotations. The browser provides a comparative view between NCBI and HuRef consensus sequences, the sequence multi-alignment of the HuRef assembly, Ensembl and dbSNP annotations, HuRef variants, and the underlying variant evidence and functional analysis. The interface also represents the
haplotype A haplotype ( haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. Many organisms contain genetic material ( DNA) which is inherited from two parents. Normally these organisms have their DNA o ...
blocks from which diploid genome sequence can be inferred and the relation of variants to gene annotations. The display of variants and gene annotations are linked to external public resources including
dbSNP The Single Nucleotide Polymorphism Database (dbSNP) is a free public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the Natio ...
, Ensembl,
Online Mendelian Inheritance in Man Online Mendelian Inheritance in Man (OMIM) is a continuously updated catalog of human genes and genetic disorders and traits, with a particular focus on the gene-phenotype relationship. , approximately 9,000 of the over 25,000 entries in OMIM ...
(OMIM) and
Gene Ontology The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and ge ...
(GO). Users can search the HuRef genome using HUGO gene names, Ensembl and dbSNP identifiers, HuRef
contig A contig (from ''contiguous'') is a set of overlapping DNA segments that together represent a consensus region of DNA.Gregory, S. ''Contig Assembly''. Encyclopedia of Life Sciences, 2005. In bottom-up sequencing projects, a contig refers to ov ...
or scaffold locations, or NCBI chromosome locations. Users can then easily and quickly browse any genomic region via the simple and intuitive pan and zoom controls; furthermore, data relevant to specific loci can be exported for further analysis.


Human Longevity, Inc.

On March 4, 2014, Venter and co-founders Peter Diamandis and Robert Hariri announced the formation of Human Longevity, Inc., a company focused on extending the healthy, "high performance" human lifespan. At the time of the announcement the company had already raised $70 million in
venture financing Venture capital financing is a type of funding by venture capital. It is private equity capital that can be provided at various stages or funding rounds. Common funding rounds include early-stage seed funding in high-potential, growth companie ...
, which was expected to last 18 months. Venter served as the chairman and
chief executive officer A chief executive officer (CEO), also known as a central executive officer (CEO), chief administrator officer (CAO) or just chief executive (CE), is one of a number of corporate executives charged with the management of an organization especiall ...
 (CEO) until May 2018, when he retired. The company said that it plans to sequence 40,000 genomes per year, with an initial focus on cancer genomes and the genomes of cancer patients. Human Longevity filed a lawsuit in 2018 against Venter, accusing him of stealing trade secrets. Allegations were made stating that Venter had departed with his company computer that contained valuable information that could be used to start a competing business. The lawsuit was ultimately dismissed by a California judge on the basis that Human Longevity were unable to present a case that met the legal threshold required for a company, or individual, to sue when its trade secrets have been stolen. Human Longevity's mission is to extend healthy human lifespan by the use of high-resolution
big data Though used sometimes loosely partly because of a lack of formal definition, the interpretation that seems to best describe Big data is the one associated with large body of information that we could not comprehend when used only in smaller am ...
diagnostics from
genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...
,
metabolomics Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprin ...
, microbiomics, and
proteomics Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. I ...
, and the use of
stem cell therapy Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. , the only established therapy using stem cells is hematopoietic stem cell transplantation. This usually takes the form of a bone-marrow transplantation, bu ...
.


Published books

Venter is the author of two books, the first of which was an autobiography titled ''A Life Decoded''. Venter's second book was titled ''Life at the Speed of Light'' in which he announced his theory that this is the generation in which there appears to be a dovetailing of the two previously diverse fields of science represented by computer programming and the genetic programming of life by DNA sequencing. He was applauded for his position on this by futurist
Ray Kurzweil Raymond Kurzweil ( ; born February 12, 1948) is an American computer scientist, author, inventor, and futurist. He is involved in fields such as optical character recognition (OCR), text-to-speech synthesis, speech recognition technology, and e ...
.


Personal life

After a brief marriage to
Barbara Rae-Venter Barbara Rae-Venter (born July 17, 1948) is a New Zealand-born American genetic genealogist, biologist, and retired patent attorney best known for her work helping police and investigators identify Joseph James DeAngelo as the Golden State Kille ...
, with whom he had a son, Christopher, he married
Claire M. Fraser Claire M. Fraser (born 1955) is an American genome scientist and microbiologist who has worked in microbial genomics and genome medicine. Her research has contributed to the understanding of the diversity and evolution of microbial life. Fraser ...
remaining married to her until 2005. In late 2008 he married Heather Kowalski. They live in the
La Jolla La Jolla ( , ) is a hilly, seaside neighborhood within the city of San Diego, California, United States, occupying of curving coastline along the Pacific Ocean. The population reported in the 2010 census was 46,781. La Jolla is surrounded on ...
neighborhood of
San Diego, CA San Diego ( , ; ) is a city on the Pacific Ocean coast of Southern California located immediately adjacent to the Mexico–United States border. With a 2020 population of 1,386,932, it is the eighth most populous city in the United States ...
. Venter is an atheist. Venter was 75 when he sold his main research facility, the J. Craig Venter Institute, to UCSD in 2022. He said he has no intention of retiring and would continue to lead a separate nonprofit research group, but he was recovering from a difficult bout with
COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quick ...
and was tired of management responsibilities. He has a home in La Jolla and a ranch in
Borrego Springs, California Borrego Springs (''Borrego'', Spanish for "Sheep") is a census-designated place (CDP) in San Diego County, California. The population was 3,429 at the 2010 census, up from 2,535 at the 2000 census, made up of both seasonal and year-round reside ...
, as well as homes in two small towns in Maine. He indulges in two passions: sailing and flying small planes, which he calls "the ultimate freedom".


In popular culture

Venter has been the subject of articles in several magazines, including ''
Wired ''Wired'' (stylized as ''WIRED'') is a monthly American magazine, published in print and online editions, that focuses on how emerging technologies affect culture, the economy, and politics. Owned by Condé Nast, it is headquartered in San ...
'',Shreeve, James
"Craig Venter's Epic Voyage to Redefine the Origin of the Species"
''
Wired ''Wired'' (stylized as ''WIRED'') is a monthly American magazine, published in print and online editions, that focuses on how emerging technologies affect culture, the economy, and politics. Owned by Condé Nast, it is headquartered in San ...
'', August 2004. Accessed June 7, 2007.
''
The Economist ''The Economist'' is a British weekly newspaper printed in demitab format and published digitally. It focuses on current affairs, international business, politics, technology, and culture. Based in London, the newspaper is owned by The Eco ...
'',"The Journey of the Sorcerer", ''
The Economist ''The Economist'' is a British weekly newspaper printed in demitab format and published digitally. It focuses on current affairs, international business, politics, technology, and culture. Based in London, the newspaper is owned by The Eco ...
'', December 4, 2004.
Australian science magazine ''
Cosmos The cosmos (, ) is another name for the Universe. Using the word ''cosmos'' implies viewing the universe as a complex and orderly system or entity. The cosmos, and understandings of the reasons for its existence and significance, are studied in ...
'',First individual person's genome decoded
- ''
Cosmos The cosmos (, ) is another name for the Universe. Using the word ''cosmos'' implies viewing the universe as a complex and orderly system or entity. The cosmos, and understandings of the reasons for its existence and significance, are studied in ...
''. September 4, 2007.
Geneticists on verge of creating artificial life
- ''Cosmos''. October 8, 2007.
and ''
The Atlantic ''The Atlantic'' is an American magazine and multi-platform publisher. It features articles in the fields of politics, foreign affairs, business and the economy, culture and the arts, technology, and science. It was founded in 1857 in Boston, ...
''. Douthat, Ross. "The God of Small Things", ''
The Atlantic ''The Atlantic'' is an American magazine and multi-platform publisher. It features articles in the fields of politics, foreign affairs, business and the economy, culture and the arts, technology, and science. It was founded in 1857 in Boston, ...
'', Jan/Feb 2007.
Venter appears in the two-hour 2001 ''
NOVA A nova (plural novae or novas) is a transient astronomical event that causes the sudden appearance of a bright, apparently "new" star (hence the name "nova", which is Latin for "new") that slowly fades over weeks or months. Causes of the dramat ...
'' special, "Cracking the code of life". On May 16, 2004, Venter gave the commencement speech at
Boston University Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original cam ...
.Warren, Jessica
April 30: Genome scientist to speak at Commencement
''The Daily Free Press'', April 28, 2004. Accessed August 2, 2008.
On December 4, 2007, Venter gave the
Dimbleby lecture The ''Richard Dimbleby Lecture'' (also known as the ''Dimbleby Lecture'') is an annual television lecture founded in memory of Richard Dimbleby (1913—1965), the BBC broadcaster. It has been delivered by an influential business, scientific or p ...
for the BBC in London. Venter delivered the 2008 convocation speech for Faculty of Science honours and specialization students at the
University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...
.Brown, M.
"Genomics leader accepts U of A honorary degree"
"UofA ExpressNews"; retrieved on June 7, 2009.
In February 2008, he gave a speech about his current work at the
TED conference TED Conferences, LLC (Technology, Entertainment, Design) is an American-Canadian non-profit media organization that posts international talks online for free distribution under the slogan "ideas worth spreading". TED was founded by Richard Sa ...
. Venter was featured in ''Time'' magazine's "The Top 10 Everything of 2008" article. Number three in 2008's Top 10 Scientific Discoveries was a piece outlining his work stitching together the 582,000 base pairs necessary to invent the genetic information for a whole new bacterium. On May 20, 2010, Venter announced the creation of first self-replicating semi-synthetic bacterial cell. In the June 2011 issue of ''
Men's Journal ''Men's Journal'' is an American monthly men's lifestyle magazine focused on outdoor recreation and comprising editorials on the outdoors, environmental issues, health and fitness, style and fashion, and gear. It was founded in 1992 by Jann Wenne ...
'', Venter was featured as the "Survival Skills" celebrity of the month. He shared various anecdotes and advice, including stories of his time in
Vietnam Vietnam or Viet Nam ( vi, Việt Nam, ), officially the Socialist Republic of Vietnam,., group="n" is a country in Southeast Asia, at the eastern edge of mainland Southeast Asia, with an area of and population of 96 million, making ...
, as well as mentioning a bout with
melanoma Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye ( ...
on his back, which subsequently resulted in his "giving a pound of flesh" to surgery. In May 2011, Venter was the commencement speaker at the 157th commencement of
Syracuse University Syracuse University (informally 'Cuse or SU) is a Private university, private research university in Syracuse, New York. Established in 1870 with roots in the Methodist Episcopal Church, the university has been nonsectarian since 1920. Locate ...
. In May 2017, Venter was the guest of honor and keynote speaker at the inauguration ceremony of the Center for Systems Biology Dresden.


Awards and nominations

* 1996: Golden Plate Award of the
American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...
* 1999:
Newcomb Cleveland Prize The Newcomb Cleveland Prize of the American Association for the Advancement of Science (AAAS) is annually awarded to author(s) of outstanding scientific paper published in the Research Articles or Reports sections of ''Science''. Established in 192 ...
* 2000: Jacob Heskel Gabbay Award in Biotechnology and Medicine * 2001:
Biotechnology Heritage Award The Biotechnology Heritage Award recognizes individuals who have made significant contributions to the development of biotechnology through discovery, innovation, and public understanding. It is presented annually at the Biotechnology Innovation ...
with
Francis Collins Francis Sellers Collins (born April 14, 1950) is an American physician-geneticist who discovered the genes associated with a number of diseases and led the Human Genome Project. He is the former director of the National Institutes of Health (N ...
, from the
Biotechnology Industry Organization The Biotechnology Innovation Organization (BIO) is the largest advocacy association in the world representing the biotechnology industry. It was founded in 1993 as the Biotechnology Industry Organization, and changed its name to the Biotechnology ...
(BIO) and the
Chemical Heritage Foundation The Science History Institute is an institution that preserves and promotes understanding of the history of science. Located in Philadelphia, Pennsylvania, it includes a library, museum, archive, research center and conference center. It was fo ...
* 2007: On May 10, 2007, Venter was awarded an honorary doctorate from
Arizona State University Arizona State University (Arizona State or ASU) is a public research university in the Phoenix metropolitan area. Founded in 1885 by the 13th Arizona Territorial Legislature, ASU is one of the largest public universities by enrollment in the ...
,Aufrett, Sarah
"ASU Celebrates Spring Graduates"
''ASU Insight'', May 11, 2007. Accessed June 7, 2007.
and on October 24 of the same year, he received an honorary doctorate from
Imperial College London Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...
."Honorary degrees awarded to Browne, Venter and Rausing"
''Imperial College'', October 24, 2007. Accessed May 21, 2010.
* 2008:
Double Helix Medal The Double Helix Medal has been awarded annually since 2006 by Cold Spring Harbor Laboratory (CSHL) to individuals who have positively impacted human health by raising awareness and funds for biomedical research. At the inaugural dinner, Muhammad ...
from
Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers ...
* 2008:
Kistler Prize The Kistler Prize (1999-2011) was awarded annually to recognize original contributions "to the understanding of the connection between human heredity and human society," and was named after its benefactor, physicist and inventor Walter Kistler. T ...
from Foundation For the Future for genome research * 2008: ENI award for Research & Environment * 2008:
National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...
from President Obama * 2010: On May 8, 2010, Venter received an honorary doctor of science degree from
Clarkson University Clarkson University is a private research university with its main campus in Potsdam, New York, and additional graduate program and research facilities in the New York Capital Region and Beacon, New York. It was founded in 1896 and has an en ...
for his work on the human genome. * 2011: On April 21, 2011, Venter received the 2011 Benjamin Rush Medal from
William & Mary School of Law The William & Mary Law School, known historically as the Marshall-Wythe School of Law, is the professional graduate law school of the College of William & Mary. Located in Williamsburg, Virginia, the school is the oldest extant law school in th ...
. * 2011:
Dickson Prize The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsburg ...
in Medicine * 2020: Edogawa NICHE Prize for his contribution to research and development pertaining to the Human genome


Works

Venter has authored over 200 publications in
scientific journal In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. Content Articles in scientific journals are mostly written by active scientists such ...
s. * * * * * * * * editor
Roger Highfield Roger Ronald Highfield (born 1958 in Griffithstown, Wales) is an author, science journalist, broadcaster and Science Director at the Science Museum Group. Education Highfield was educated at Chase Side Primary School in Enfield and Christ's H ...
* editor
Roger Highfield Roger Ronald Highfield (born 1958 in Griffithstown, Wales) is an author, science journalist, broadcaster and Science Director at the Science Museum Group. Education Highfield was educated at Chase Side Primary School in Enfield and Christ's H ...


See also

*
Artificial gene synthesis Artificial gene synthesis, or simply gene synthesis, refers to a group of methods that are used in synthetic biology to construct and assemble genes from nucleotides '' de novo''. Unlike DNA synthesis in living cells, artificial gene synthesis do ...
*
Full genome sequencing Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a ...
*
Genetic testing Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression, or ...
* '' Genome: The Autobiography of a Species in 23 Chapters'' *
Personal genomics Personal genomics or consumer genetics is the branch of genomics concerned with the sequencing, analysis and interpretation of the genome of an individual. The genotyping stage employs different techniques, including single-nucleotide polymorphi ...
*
Pharmacogenomics Pharmacogenomics is the study of the role of the genome in drug response. Its name ('' pharmaco-'' + ''genomics'') reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects the ...
* Predictive medicine * Synthetic Organism Designer


References


Further reading

* * *


External links


Human Longevity, Inc.HuRef Genome BrowserJ. Craig Venter InstituteSynthetic Genomics

The Institute for Genomic Research (TIGR)
; Media * * *
Cracking the code to life
''
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers '' The Observer'' and '' The Guardian Weekly'', ''The Guardian'' is part of the ...
'', October 8, 2007
Craig Venter interview
''
Wired Science ''Wired Science'' was a weekly television program that covered modern scientific and technological topics. In January 2007 PBS aired pilot episodes for three different science programs, including ''Wired Science''. Using Nielsen ratings, CPB-sp ...
'', December 2007 (video)
Video of interview/discussion with Craig Venter
by
Carl Zimmer Carl Zimmer (born 1966) is a popular science writer, blogger, columnist, and journalist who specializes in the topics of evolution, parasites, and heredity. The author of many books, he contributes science essays to publications such as ''The ...
on
Bloggingheads.tv Bloggingheads.tv (sometimes abbreviated "bhtv") is a political, world events, philosophy, and science video blog discussion site in which the participants take part in an active back and forth conversation via webcam which is then broadcast on ...
* – TED (Technology Entertainment Design) conference (video)
Webcast of Venter talk 'Genomics: From humans to the environment'
at The James Martin 21st Century School
The Richard Dimbleby Lecture 2007 – Dr. J. Craig Venter – A DNA Driven World
* {{DEFAULTSORT:Venter, Craig 1946 births Living people American atheists American chairpersons of corporations American corporate directors American geneticists American technology chief executives American technology company founders Biotechnologists Human Genome Project scientists Leeuwenhoek Medal winners Life extensionists Members of the United States National Academy of Sciences Military personnel from Salt Lake City Researchers of artificial life Scientists from Salt Lake City United States Navy corpsmen United States Navy personnel of the Vietnam War University at Buffalo faculty University of California, San Diego alumni Members of the National Academy of Medicine