The philosopher David Hume used the phrase frequently in his discussion of the limits of empiricism to explain our ideas of causation and inference. In An Enquiry concerning Human Understanding and A Treatise of Human Nature Hume proposed that the origin of our knowledge of necessary connections arises out of observation of the constant conjunction of certain impressions across many instances. A more modern conception would argue that scientific law is distinguishable from a principle that arises merely accidentally because of the constant conjunction of one thing and another, but there is considerable controversy over what this distinguishing feature might be.
Although British empiricism and associationist philosophers elaborated on Hume's fundamental idea in many diverse ways, and metaphysicians like Immanuel Kant tried to dissipate the position,[verification needed] the force of his arguments has remained remarkably robust, and they have found unexpected support in three scientific discoveries of the 20th century: Ivan Pavlov's laws of conditioning; Hebbian neural networks; and spike-timing-dependent plasticity (STDP).
In Pavlov's framework, an unconditioned stimulus can follow in constant conjunction a conditioning/conditioned stimulus within a timeframe of milliseconds to several seconds, and result in the conditioned stimulus having many of the properties of the unconditioned stimulus. Donald Hebb explained this as an intrinsic property of cell assemblies within the nervous system to form connections within large cliques of cells whenever those cells fire together within a reasonably short period of time. (A modern shorthand for his ideas states: "Cells that fire together, wire together".) Modern neuroscience has confirmed this insight as a product of the activity of synapses and STDP, so structured to strengthen connections between cells that fire within very short periods (10s of milliseconds) of each other. The longer time periods of classical conditioning are presumably a large-number effect of cliques of these synapses and cells.