Complement 3 deficiency is a genetic condition affecting
complement component 3
Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called ''C3''.
Function
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(C3). People can suffer from either primary or secondary C3 deficiency. Primary C3 deficiency refers to an inherited autosomal-recessive disorder that involves mutations in the gene for C3.
Secondary C3 deficiency results from a lack of
factor I or
factor H
Factor H is a member of the regulators of complement activation family and is a complement control protein. It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at typical concentrations of 200–300 micrograms ...
, two proteins that are key for the regulation of C3.
Both primary and secondary C3 deficiency are characterized by low levels or absence of C3.
C3 function
Complement component 3
Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called ''C3''.
Function
...
(C3) is a protein involved in both the