Cobalt poisoning is

intoxication Intoxication — or poisoning, especially by an alcoholic or narcotic substance — may refer to: * Substance intoxication: ** Alcohol intoxication ** LSD intoxication ** Toxidrome ** Tobacco intoxication ** Cannabis intoxication ** Cocaine i ...

caused by excessive levels of

cobalt Cobalt is a chemical element with the symbol Co and atomic number 27. As with nickel, cobalt is found in the Earth's crust only in a chemically combined form, save for small deposits found in alloys of natural meteoric iron. The free element, p ...

in the body. Cobalt is an essential element for health in animals in minute amounts as a component of

Vitamin B B vitamins are a class of water-soluble vitamins that play important roles in cell metabolism and synthesis of red blood cells. Though these vitamins share similar names (B1, B2, B3, etc.), they are chemically distinct compounds that often coex ...

. A deficiency of cobalt, which is very rare, is also potentially lethal, leading to

pernicious anemia Pernicious anemia is a type of vitamin B12 deficiency anemia, a disease in which not enough red blood cells are produced due to the malabsorption of vitamin B12. Malabsorption in pernicious anemia results from the lack or loss of intrinsic fa ...

. Exposure to cobalt metal dust is most common in the fabrication of

tungsten carbide Tungsten carbide (chemical formula: WC) is a chemical compound (specifically, a carbide) containing equal parts of tungsten and carbon atoms. In its most basic form, tungsten carbide is a fine gray powder, but it can be pressed and formed into ...

. Another source is from

wear and tear Wear and tear is damage that naturally and inevitably occurs as a result of normal wear or aging. It is used in a legal context for such areas as warranty contracts from manufacturers, which usually stipulate that damage from ''wear and tear'' w ...

of certain metal-on-metal hip prostheses. Per the

International Agency for Research on Cancer The International Agency for Research on Cancer (IARC; french: Centre International de Recherche sur le Cancer, CIRC) is an intergovernmental agency forming part of the World Health Organization of the United Nations. Its role is to conduct and ...

(IARC), cobalt metal with

is "''probably

carcinogen A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive subs ...

ic to humans''" ( IARC Group 2A Agent), whereas cobalt metal without

is "''possibly

ic to humans''" ( IARC Group 2B Agent).

Cobalt salts

The value for soluble cobalt salts has been estimated to be between 150 and 500 mg/kg. Thus, for a 100 kg person the LD₅₀ would be about 20 grams. Soluble cobalt(II) salts are "''possibly

ic to humans''" ( IARC Group 2B Agents).

Beer drinker's cardiomyopathy

In August 1965, a person presented to a hospital in

Quebec City Quebec City ( or ; french: Ville de Québec), officially Québec (), is the capital city of the Canadian province of Quebec. As of July 2021, the city had a population of 549,459, and the metropolitan area had a population of 839,311. It is t ...

with symptoms suggestive of

alcoholic cardiomyopathy Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol) leads to heart failure. Alcoholic cardiomyopathy is a type of dilated cardiomyopathy. Due to the direct toxic effects of alcohol on heart muscle ...

. Over the next eight months, fifty more cases with similar findings appeared in the same area with twenty of these being fatal. It was noted that all were heavy drinkers who mostly drank beer and preferred the Dow brand; thirty out of those drank more than 6 litres (12 pints) of beer per day.

Epidemiological studies Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evid ...

found that Dow had been adding cobalt sulfate to the beer for

foam Foams are materials formed by trapping pockets of gas in a liquid or solid. A bath sponge and the head on a glass of beer are examples of foams. In most foams, the volume of gas is large, with thin films of liquid or solid separating the ...

stability since July 1965 and that the concentration added in the Quebec city brewery was ten times that of the same beer brewed in

Montreal Montreal ( ; officially Montréal, ) is the second-most populous city in Canada and most populous city in the Canadian province of Quebec. Founded in 1642 as '' Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple ...

where there were no reported cases. A 1972 paper noted that several dozen cases were also identified over a similar time period in Omaha, Nebraska; Minneapolis, Minnesota; and Belgium.

Cobalt in the environment

Plants, animals, and humans can all be affected by high cobalt concentrations in the environment. For plants, the uptake and distribution of cobalt is entirely species-specific. In some species of plants, the overaccumulation of cobalt can lead to an

iron deficiency Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key ...

. This in turn leads to poor growth of the plant as well as leaf loss which overall decreases the amount of oxygen produced by plants during

photosynthesis Photosynthesis is a process used by plants and other organisms to convert light energy into chemical energy that, through cellular respiration, can later be released to fuel the organism's activities. Some of this chemical energy is stored i ...

. Eventually the deficiency would lead to plant death. One such example was seen in an experiment involving the effects of increased cobalt concentration on

tomato The tomato is the edible berry of the plant ''Solanum lycopersicum'', commonly known as the tomato plant. The species originated in western South America, Mexico, and Central America. The Mexican Nahuatl word gave rise to the Spanish word ...

plants. As the dosage of cobalt in the soil surrounding the plants increased, so too did the rate of necrosis of the leaves of the tomato plant. Over time this led to an inability of the plant to produce fruit and eventually the plant died.

References

External links

{{Elements in biology Cobalt Toxic effects of metals