CUMYL-THPINACA (also known as SGT-42) is an

indazole Indazole, also called isoindazole, is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and pyrazole. Indazole is an amphoteric molecule which can be protonated to an indazolium cation or deproton ...

-3-carboxamide based

synthetic cannabinoid Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids ( THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthe ...

. CUMYL-THPINACA acts as a potent

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

for the

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid recep ...

s, with approximately 6x selectivity for CB₁, having an EC₅₀ of 0.1nM for human CB₁ receptors and 0.59nM for human CB₂ receptors.

Legal status

Sweden's public health agency suggested to classify CUMYL-THPINACA as hazardous substance on November 10, 2014. As of October 2015 CUMYL-THPINACA is a controlled substance in China.

References

Cannabinoids Designer drugs Indazolecarboxamides {{cannabinoid-stub

Legal status

See also

References