CD49d is an
integrin
Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle ...
alpha subunit. It makes up half of the α4β1
lymphocyte homing receptor.
Function
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Interactions
CD49d has been shown to
interact
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with
LGALS8 and
Paxillin.
See also
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Carotegrast methyl
Carotegrast methyl (trade name Carogra) is a drug used for the treatment of ulcerative colitis.
Carotegrast methyl is a prodrug that has little pharmacological activity itself. The methyl ester, which is designed to enhance oral bioavailability, ...
, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis
References
Further reading
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External links
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ITGA4Info with links in th
Cell Migration Gateway
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Integrins
Clusters of differentiation
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