Brain-specific angiogenesis inhibitor 3 is a
protein that in humans is encoded by the ''BAI3''
gene.
BAI1, a p53-target gene, encodes brain-specific
angiogenesis
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature by processes of sprouting and splitting ...
inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.
The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.
The adhesion GPCR BaI3 is an orphan receptor that has a long
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.
BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub