Bone morphogenetic protein receptors are
serine-threonine kinase
A serine/threonine protein kinase () is a kinase enzyme, in particular a protein kinase, that phosphorylation, phosphorylates the hydroxyl, OH group of the amino acid, amino-acid residues serine or threonine, which have similar side chains. ...
receptors.
Transforming growth factor beta family
The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally described in 1983. They interact with TGF-beta receptors.
Ma ...
proteins bind to these receptors. There are four bone morphogenetic protein receptors:
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Bone morphogenetic protein receptor, type 1
Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. They belong to a class of receptor serine/threonine kinases that bind members of the TGF beta superfamily of ligands-the Bone morphogenetic proteins.
Th ...
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ACVR1
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ''ACVR1'' gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bo ...
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BMPR1A
The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the ''BMPR1A'' gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).
Function
The bone morphogenetic pr ...
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BMPR1B
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Bone morphogenetic protein receptor, type 2
Structure
Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.
Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the
SMAD signaling cascade.
The wrist epitope motif on
BMP-2
The BMP-2 (''Boyevaya Mashina Pekhoty'', , literally "combat machine/vehicle (of the) infantry") is an amphibious infantry fighting vehicle introduced in the 1980s in the Soviet Union, following on from the BMP-1 of the 1960s.
Development hist ...
has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.
See also
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Bone morphogenetic protein
References
External links
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Bone morphogenetic protein
EC 2.7.11
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