Barbara Sahakian
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Barbara Jacquelyn Sahakian, is
Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professo ...
of Clinical Neuropsychology at the Department of Psychiatry and Medical Research Council (MRC)/
Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
Behavioural and Clinical Neuroscience Institute,
University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...
. She is also an Honorary
Clinical Psychologist Clinical psychology is an integration of social science, theory, and clinical knowledge for the purpose of understanding, preventing, and relieving psychologically based distress or dysfunction and to promote subjective well-being and persona ...
at
Addenbrooke's Hospital Addenbrooke's Hospital is an internationally renowned large teaching hospital and research centre in Cambridge, England, with strong affiliations to the University of Cambridge. Addenbrooke's Hospital is based on the Cambridge Biomedical Camp ...
,
Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...
. She has an international reputation in the fields of cognitive
psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on mo ...
,
neuroethics In philosophy and neuroscience, Neuroethics is the study of both the ethics of neuroscience and the neuroscience of ethics. The ethics of neuroscience comprises the bulk of work in neuroethics. It concerns the ethical, legal and social impact of n ...
,
neuropsychology Neuropsychology is a branch of psychology concerned with how a person's cognition and behavior are related to the brain and the rest of the nervous system. Professionals in this branch of psychology often focus on how injuries or illnesses of t ...
,
neuropsychiatry Neuropsychiatry or Organic Psychiatry is a branch of medicine that deals with psychiatry as it relates to neurology, in an effort to understand and attribute behavior to the interaction of neurobiology and social psychology factors. Within neurop ...
and
neuroimaging Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Incr ...
. Sahakian is a fellow of
Clare Hall, Cambridge Clare Hall is a constituent college of the University of Cambridge, England. Founded in 1966 by Clare College, Clare Hall is a college for advanced study, admitting only postgraduate students alongside postdoctoral researchers and fellows. It ...
. She is currently President of the
International Neuroethics Society The International Neuroethics Society (INS) is a professional organization that studies the social, legal, ethical, and policy implications of advances in neuroscience. Its mission is to encourage and inspire research and dialogue on the responsible ...
(INS), of which she is a founder member. She is Past-President of the British Association for Psychopharmacology (BAP), having served as president from 2012 to 2014.


Education

Sahakian completed her PhD in
Psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on mo ...
at
Darwin College, Cambridge Darwin College is a constituent college of the University of Cambridge. Founded on 28 July 1964, Darwin was Cambridge University's first graduate-only college, and also the first to admit both men and women. The college is named after one of th ...
in the Department of Psychology at the University of Cambridge. Following this, Sahakian studied for a Diploma in Clinical Psychology and became a Chartered Psychologist.


Career

Sahakian is best known for her work on cognitive enhancement using pharmacological treatments, early detection of
Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As ...
, cognition and depression and neuroethics. Sahakian's research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction to develop more effective pharmacological and psychological treatments. The focus of her lab is on early detection of neuropsychiatric disorders, differential diagnosis and proof of concept studies using cognitive enhancing drugs and cognitive training. In her research, Sahakian uses techniques such as psychopharmacological, neuropsychological and neuroimaging (
fMRI Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area ...
and
PET A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive appearances, intelligence ...
). Key research areas for her group are Alzheimer's disease, Attention Deficit Hyperactivity Disorder (ADHD), Obsessive Compulsive Disorder (OCD),
substance abuse Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods which are harmful to the individual or others. It is a form of substance-related disorder. Differing definitions of drug abuse are used in public health, ...
, depression and
mania Mania, also known as manic syndrome, is a mental and behavioral disorder defined as a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together wi ...
. In 2007, Sahakian raised concerns regarding the ethics of using drugs intended to help
dementia Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affe ...
and Alzheimer's patients to instead enhance cognitive function in healthy people. In May 2014, Sahakian published an article on the subject of achieving brain health for a flourishing society within the next decade. In this article, she included a list of experts from a range of areas, including neuroscience, innovation and technology. Sahakian was asked to write this article for
Sir John Beddington Sir John Rex Beddington HonFREng (born 13 October 1945) is a British population biologist and Senior Adviser at the Oxford Martin School, and was previously Professor of Applied Population Biology at Imperial College London, and the UK Gover ...
, Chief Scientific Adviser to the UK Government. Sahakian has published over 400 papers covering these topics in scientific journals, including many publications in the prestigious scientific and medical journals ''
Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence ...
'', ''
Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...
'', ''
Nature Neuroscience ''Nature Neuroscience'' is a monthly scientific journal published by Nature Publishing Group. Its focus is original research papers relating specifically to neuroscience and was established in May 1998. The chief editor is Shari Wiseman. According ...
'', ''
The Lancet ''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles ...
'', and the ''
British Medical Journal ''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Origi ...
''. She is an Associate Editor of Psychological Medicine. The ISI Web of Science database credits her with a Hirsch (h) Index of 100. Sahakian is co-author of 'Bad Moves. How decision making goes wrong and the ethics of smart drugs', published by
Oxford University Press Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print book ...
in 2013. She is also co-editor of 'The Oxford Handbook of Neuroethics', published in 2011 by Oxford University Press. In addition to her Presidencies of the BAP and INS, Sahakian is also on the council of the International College of Neuropsychopharmacology (CINP) and on the European College of Neuropsychopharmacology (ECNP) Review Board. She is also a London Imperial Affiliated Professor and a Distinguished
Research fellow A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a pr ...
at the
Oxford Uehiro Centre for Practical Ethics The Faculty of Philosophy, University of Oxford was founded in 2001. It is part of Oxford's Humanities Division. The faculty is located next to Somerville College on Woodstock Road. As of 2020, it is ranked 1st in the UK and 2nd in the English- ...
. Previously, Sahakian has been a member of the MRC Neurosciences and Mental Health Board (2006–2010) and a member of the Society for Neuroscience (SfN) Committee on Women in Neuroscience. Recently, a
Royal Institution The Royal Institution of Great Britain (often the Royal Institution, Ri or RI) is an organisation for scientific education and research, based in the City of Westminster. It was founded in 1799 by the leading British scientists of the age, inc ...
article named Barbara Sahakian amongst the top women in science.


Inventions

Sahakian's research uses neuropsychological tests, such as the Cambridge Neuropsychological Test Automated Battery (CANTAB) tests, which she co-invented in the 1980s. CANTAB is now used at over 700 research institutes worldwide and is backed by over 1,200 peer-review articles. Sahakian serves as a Senior Consultant to Cambridge Cognition, a spin-out of the University of Cambridge. Cambridge Cognition now provides CANTAB. The CANTAB PAL touchscreen test, which assesses
visual memory Visual memory describes the relationship between perceptual processing and the encoding, storage and retrieval of the resulting neural representations. Visual memory occurs over a broad time range spanning from eye movements to years in order ...
and new learning, received the highest rating of world-leading 4* grade from the
Research Excellence Framework The Research Excellence Framework (REF) is a research impact evaluation of British higher education institutions. It is the successor to the Research Assessment Exercise and it was first used in 2014 to assess the period 2008–2013. REF is under ...
(REF) 2014. Following this award, CANTAB and CANTAB PAL were highlighted in the Medical Schools Council 'Health of the Nation' 2015 publication, which described CANTAB as a boost to the UK economy.


Neuroscience and mental health policy

Sahakian is a lead on many high-impact international neuroscience and mental health policy reports, including the National Institute of Mental Health (NIMH) funded report on Grand Challenges in Global Mental Health and the
UK Government ga, Rialtas a Shoilse gd, Riaghaltas a Mhòrachd , image = HM Government logo.svg , image_size = 220px , image2 = Royal Coat of Arms of the United Kingdom (HM Government).svg , image_size2 = 180px , caption = Royal Arms , date_est ...
Foresight Project on Mental Capital and Wellbeing in 2008. The latter project emphasised good brain health and wellbeing throughout the life course and highlighted important concepts, such as cognitive reserve and resilience to stress. Sahakian recently presented on neuroscience and mental health policy at the World Economic Forum (WEF) 2014 in
Davos, Switzerland , neighboring_municipalities= Arosa, Bergün/Bravuogn, Klosters-Serneus, Langwies, S-chanf, Susch , twintowns = } Davos (, ; or ; rm, ; archaic it, Tavate) is an Alpine resort town and a municipality in the Prättigau/Davos R ...
. She is a Member of the WEF Global Agenda Council on Brain Research.


Press

Sahakian frequently engages the public in science, appearing on programmes such as
BBC Newsnight ''Newsnight'' (or ''BBC Newsnight'') is BBC Two's news and current affairs programme, providing in-depth investigation and analysis of the stories behind the day's headlines. The programme is broadcast on weekdays at 22:30. and is also availab ...
, and on both
The Life Scientific ''The Life Scientific'' is a BBC Radio 4 science programme, presented by Professor Jim Al-Khalili , in which each episode is dedicated to the biography and work of one living scientist. The programme consists of an interview between Al-Khalili ...
and the
Today Programme ''Today'', colloquially known as ''the Today programme'', is a long-running British morning news and current-affairs Radio program, radio programme on BBC Radio 4. Broadcast on Monday to Saturday from 6:00 am to 9:00 am, it is produced by BBC N ...
on
BBC Radio 4 BBC Radio 4 is a British national radio station owned and operated by the BBC that replaced the BBC Home Service in 1967. It broadcasts a wide variety of spoken-word programmes, including news, drama, comedy, science and history from the BBC's ...
. She has also taken part in numerous newspaper interviews, such as
The Sunday Times ''The Sunday Times'' is a British newspaper whose circulation makes it the largest in Britain's quality press market category. It was founded in 1821 as ''The New Observer''. It is published by Times Newspapers Ltd, a subsidiary of News UK, whi ...
and Forbes Online. In 2012, Sahakian contributed to the catalogue and appeared in a video for the Wellcome Trust Superhuman Exhibition. In May 2014, she took part in a
Reddit Reddit (; stylized in all lowercase as reddit) is an American social news aggregation, content rating, and discussion website. Registered users (commonly referred to as "Redditors") submit content to the site such as links, text posts, imag ...
Ask Me Anything (AMA), fielding questions on a range of subjects, such as depression and cognitive enhancing drugs. In July 2014, Sahakian dispelled the myth that humans only use 10% of their brains in regard to the plot of the film
Lucy Lucy is an English feminine given name derived from the Latin masculine given name Lucius with the meaning ''as of light'' (''born at dawn or daylight'', maybe also ''shiny'', or ''of light complexion''). Alternative spellings are Luci, Luce, Lu ...
. In March 2015, she advised on the 'You have been upgraded' event at the
Science Museum A science museum is a museum devoted primarily to science. Older science museums tended to concentrate on static displays of objects related to natural history, paleontology, geology, industry and industrial machinery, etc. Modern trends in ...
in London, which featured demonstrations by members of her Laboratory. In the context of presentations on neuroscience, brain health, cognitive enhancement and neuropsychiatric disorders, she has frequently stated the importance of understanding brain health and disease.


Honours and awards

Since 2004, Sahakian has been a Fellow of the
Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to adv ...
. She is also associated with the
Human Brain Project The Human Brain Project (HBP) is a large ten-year scientific research project, based on exascale supercomputers, that aims to build a collaborative ICT-based scientific research infrastructure to allow researchers across Europe to advance knowl ...
. Sahakian is also a Member of the International Expert Jury for the 2017 Else Kröner-Fresenius-Stiftung Prize. Sahakian was he was appointed to the F C Donders Chair of Psychopharmacology at the
University of Utrecht Utrecht University (UU; nl, Universiteit Utrecht, formerly ''Rijksuniversiteit Utrecht'') is a public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2018, it had an enrollme ...
in 2005 and the Distinguished International Scholar Award at the
University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a Private university, private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest- ...
in 2009. In 2010, she received the International College of Geriatric Psychoneuropharmacology (ICGP) Senior Investigator Award. In 2008, Sahakian gave the
Alfred Deakin Alfred Deakin (3 August 1856 – 7 October 1919) was an Australian politician who served as the second Prime Minister of Australia. He was a leader of the movement for Federation, which occurred in 1901. During his three terms as prime ministe ...
Innovation Lecture in
Melbourne, Australia Melbourne ( ; Boonwurrung/Woiwurrung: ''Narrm'' or ''Naarm'') is the capital and most populous city of the Australian state of Victoria, and the second-most populous city in both Australia and Oceania. Its name generally refers to a metr ...
. In 2015, Sahakian was awarded a
Doctor of Science Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...
degree from the University of Cambridge, which is the highest degree awarded by the university for distinguished research in science. In July 2017, Sahakian was elected a
Fellow of the British Academy Fellowship of the British Academy (FBA) is an award granted by the British Academy to leading academics for their distinction in the humanities and social sciences. The categories are: # Fellows – scholars resident in the United Kingdom # ...
(FBA), the United Kingdom's
national academy A national academy is an organizational body, usually operating with state financial support and approval, that co-ordinates scholarly research activities and standards for academic disciplines, most frequently in the sciences but also the hu ...
for the humanities and social sciences.


Publications

* Mental Capital and Wellbeing (2009) * Oxford Handbook of Neuroethics (2011) * Bad Moves: How Decision Making Goes Wrong, and the Ethics of Smart Drugs (2013) * Sex, Lies, and Brain Scans: How FMRI Reveals what Really Goes on in Our Minds (2016) * Translational Neuropsychopharmacology (2016)


References


External links


Professor Barbara Sahakian: Cambridge NeuroscienceProfessor Barbara Sahakian: Behavioural and Clinical Neuroscience Institute
{{DEFAULTSORT:Sahakian, Barbara Living people English neuroscientists British psychologists British women neuroscientists Fellows of the Academy of Medical Sciences (United Kingdom) Fellows of Clare Hall, Cambridge Alumni of Darwin College, Cambridge Alumni of the University of Cambridge Fellows of the British Academy Year of birth missing (living people)