Transforming growth factor beta-3 is a protein that in humans is encoded by the gene.
It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and developmental biology, development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF beta, TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.
TGF-β3 is believed to regulate molecules involved in cell adhesion, cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of Epidermis (skin), epidermal and dermis, dermal cells in injured skin.
Interactions
Transforming growth factor, beta 3 has been shown to Protein-protein interaction, interact with TGF beta receptor 2.
Clinical research
After successful phase I/II clinical trial, trials, human recombinant TGF-β3 (Avotermin, planned trade name Juvista) failed in Phase III trials.
Renovo shares plummet 75% as scar revision product Juvista fails to meet study endpoints
14 February 2011
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
OMIM entries on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, Autosomal Dominant
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{{TGFβ receptor superfamily modulators
Proteins
TGFβ domain