Astressin-B is a nonselective

corticotropin releasing hormone antagonist A Corticotropin-releasing hormone antagonist (CRH antagonist) is a specific type of receptor antagonist that blocks the receptor sites for corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF), which synchronizes the b ...

that reduces the synthesis of

adrenocorticotropic hormone Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important c ...

and cortisol. It reduces the synthesis of adrenocorticotropic hormone and improves the sexual drive of rats under stressing conditions. Astressin-B is able to delay the emptying of solid food in mice. Astressin-B can prevent the release of adrenocorticotropic hormone in mice due to shock, alcohol and

endotoxemia Lipopolysaccharides (LPS) are large molecules consisting of a lipid and a polysaccharide that are bacterial toxins. They are composed of an O-antigen, an outer core, and an inner core all joined by a covalent bond, and are found in the outer m ...

. Treatment with astressin-B caused the sudden growth of hair in mice bred for a propensity for

stress Stress may refer to: Science and medicine * Stress (biology), an organism's response to a stressor such as an environmental condition * Stress (linguistics), relative emphasis or prominence given to a syllable in a word, or to a word in a phrase ...

References

Corticotropin-releasing hormone Corticotropin-releasing hormone antagonists {{biochem-stub