Androsterone sulfate, also known as 3α-hydroxy-5α-androstan-17-one 3α-sulfate, is an
endogenous,
naturally occurring
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical sy ...
steroid and one of the major
urinary
The urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, co ...
metabolites of
androgen
An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This in ...
s.
It is a
steroid sulfate which is formed from
sulfation
Sulfation is the chemical reaction that entails the addition of SO3 group. In principle, many sulfations would involve reactions of sulfur trioxide (SO3). In practice, most sulfations are effected less directly. Regardless of the mechanism, the ...
of
androsterone
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of test ...
by the
steroid sulfotransferase SULT2A1
Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the ''SULT2A1'' gene.
Function
Sulfotransferase enzymes catalyze the sulfate conjugation ...
and can be
desulfated back into androsterone by
steroid sulfatase.
See also
*
Androsterone glucuronide
Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). It accounts for 93% of total androgen glucuronides in women. ADT-G is formed from androsterone by UDP-glucuronosyltrans ...
*
Steroid sulfate
*
C19H30O5S
References
External links
Metabocard for Androsterone Sulfate (HMDB02759) - Human Metabolome Database
5α-Reduced steroid metabolites
Androgen esters
Androstanes
Human metabolites
Ketones
Sulfate esters
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