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1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP

Identifiers Aliases AMY1A, AMY1, amylase, alpha 1A (salivary) External IDs HomoloGene: 133998 GeneCards: AMY1A
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AMY1A
Genomic location for AMY1A
Band 1p21.1 Start 103,655,290 bp[1]
End 103,664,554 bp[1]
Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004038
NM_001008221

n/a

RefSeq (protein)

NP_001008220
NP_001333709

n/a

Location (UCSC) Chr 1: 103.66 – 103.66 Mb n/a PubMed search [2] n/a Wikidata
View/Edit Human

Alpha-amylase 1 is an enzyme that in humans is encoded by the AMY1A gene.[3] This gene is found in many organisms, see Alpha-Amylase.

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.[3]

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Further reading